Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry

Variants within the gene cluster encoding α3, α5, and β4 nicotinic receptor subunits are major risk factors for substance dependence. The strongest impact on risk is associated with variation in the CHRNA5 gene, where at least two mechanisms are at work: amino acid variation and altered mRNA express...

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Detalles Bibliográficos
Autores principales: Wang, Jen-Chyong, Spiegel, Noah, Bertelsen, Sarah, Le, Nhung, McKenna, Nicholas, Budde, John P., Harari, Oscar, Kapoor, Manav, Brooks, Andrew, Hancock, Dana, Tischfield, Jay, Foroud, Tatiana, Bierut, Laura J., Steinbach, Joe Henry, Edenberg, Howard J., Traynor, Bryan J., Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841173/
https://www.ncbi.nlm.nih.gov/pubmed/24303001
http://dx.doi.org/10.1371/journal.pone.0080204

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