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Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis

BACKGROUND: Intracranial arterial stenosis (ICAS) is the predominant cause of ischemic stroke and transient ischemic attack in Asia. Change of signal intensities (SI) across an ICAS on magnetic resonance angiography (MRA) may reflect its hemodynamic severity. METHODS: In-patients with a symptomatic...

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Autores principales: Leng, Xinyi, Wong, Ka Sing, Soo, Yannie, Leung, Thomas, Zou, Xinying, Wang, Yongjun, Feldmann, Edward, Liu, Liping, Liebeskind, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841201/
https://www.ncbi.nlm.nih.gov/pubmed/24302997
http://dx.doi.org/10.1371/journal.pone.0080124
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author Leng, Xinyi
Wong, Ka Sing
Soo, Yannie
Leung, Thomas
Zou, Xinying
Wang, Yongjun
Feldmann, Edward
Liu, Liping
Liebeskind, David S.
author_facet Leng, Xinyi
Wong, Ka Sing
Soo, Yannie
Leung, Thomas
Zou, Xinying
Wang, Yongjun
Feldmann, Edward
Liu, Liping
Liebeskind, David S.
author_sort Leng, Xinyi
collection PubMed
description BACKGROUND: Intracranial arterial stenosis (ICAS) is the predominant cause of ischemic stroke and transient ischemic attack in Asia. Change of signal intensities (SI) across an ICAS on magnetic resonance angiography (MRA) may reflect its hemodynamic severity. METHODS: In-patients with a symptomatic single ICAS detected on 3D time-of-flight MRA were recruited from 2 hospitals. Baseline and 1-year follow-up data were collected. Signal intensity ratio (SIR) [ =  (mean post-stenotic SI -mean background SI)/(mean pre-stenotic SI - mean background SI)] was evaluated on baseline MRA to represent change of SIs across an ICAS. Acute infarct volume was measured on baseline diffusion-weighted images (DWI). Relationships between SIR and baseline characteristics as well as 1y outcomes were evaluated. RESULTS: Thirty-six subjects (86.1% males, mean age 55.0) were recruited. Overall, mean SIR was 0.84±0.23. Mean SIRs were not significantly different between the 23 (63.9%) anatomically severe stenoses and the 13 (36.1%) anatomically moderate stenoses (0.80±0.23 versus 0.92±0.21, p = 0.126). SIR was significantly, linearly and negatively correlated to acute infarct volume on DWI (Spearman correlation coefficient −0.471, p = 0.011). Two patients (5.6%) had recurrent ischemic strokes at 1y, not related to SIR values. CONCLUSIONS: Change of signal intensities across an ICAS on MRA may reflect its hemodynamic and functional severity. Future studies are warranted to further verify the relationships between this index and prognosis of patients with symptomatic ICAS.
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spelling pubmed-38412012013-12-03 Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis Leng, Xinyi Wong, Ka Sing Soo, Yannie Leung, Thomas Zou, Xinying Wang, Yongjun Feldmann, Edward Liu, Liping Liebeskind, David S. PLoS One Research Article BACKGROUND: Intracranial arterial stenosis (ICAS) is the predominant cause of ischemic stroke and transient ischemic attack in Asia. Change of signal intensities (SI) across an ICAS on magnetic resonance angiography (MRA) may reflect its hemodynamic severity. METHODS: In-patients with a symptomatic single ICAS detected on 3D time-of-flight MRA were recruited from 2 hospitals. Baseline and 1-year follow-up data were collected. Signal intensity ratio (SIR) [ =  (mean post-stenotic SI -mean background SI)/(mean pre-stenotic SI - mean background SI)] was evaluated on baseline MRA to represent change of SIs across an ICAS. Acute infarct volume was measured on baseline diffusion-weighted images (DWI). Relationships between SIR and baseline characteristics as well as 1y outcomes were evaluated. RESULTS: Thirty-six subjects (86.1% males, mean age 55.0) were recruited. Overall, mean SIR was 0.84±0.23. Mean SIRs were not significantly different between the 23 (63.9%) anatomically severe stenoses and the 13 (36.1%) anatomically moderate stenoses (0.80±0.23 versus 0.92±0.21, p = 0.126). SIR was significantly, linearly and negatively correlated to acute infarct volume on DWI (Spearman correlation coefficient −0.471, p = 0.011). Two patients (5.6%) had recurrent ischemic strokes at 1y, not related to SIR values. CONCLUSIONS: Change of signal intensities across an ICAS on MRA may reflect its hemodynamic and functional severity. Future studies are warranted to further verify the relationships between this index and prognosis of patients with symptomatic ICAS. Public Library of Science 2013-11-26 /pmc/articles/PMC3841201/ /pubmed/24302997 http://dx.doi.org/10.1371/journal.pone.0080124 Text en © 2013 Leng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Leng, Xinyi
Wong, Ka Sing
Soo, Yannie
Leung, Thomas
Zou, Xinying
Wang, Yongjun
Feldmann, Edward
Liu, Liping
Liebeskind, David S.
Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title_full Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title_fullStr Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title_full_unstemmed Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title_short Magnetic Resonance Angiography Signal Intensity as a Marker of Hemodynamic Impairment in Intracranial Arterial Stenosis
title_sort magnetic resonance angiography signal intensity as a marker of hemodynamic impairment in intracranial arterial stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841201/
https://www.ncbi.nlm.nih.gov/pubmed/24302997
http://dx.doi.org/10.1371/journal.pone.0080124
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