BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures

Human embryonic stem cells (hESCs) regularly acquire nonrandom genomic aberrations during culture, raising concerns about their safe therapeutic application. The International Stem Cell Initiative identified a copy number variant (CNV) amplification of chromosome 20q11.21 in 25% of hESC lines displa...

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Detalles Bibliográficos
Autores principales: Avery, Stuart, Hirst, Adam J., Baker, Duncan, Lim, Chin Yan, Alagaratnam, Sharmini, Skotheim, Rolf I., Lothe, Ragnhild A., Pera, Martin F., Colman, Alan, Robson, Paul, Andrews, Peter W., Knowles, Barbara B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841249/
https://www.ncbi.nlm.nih.gov/pubmed/24286026
http://dx.doi.org/10.1016/j.stemcr.2013.10.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841249/
https://www.ncbi.nlm.nih.gov/pubmed/24286026
http://dx.doi.org/10.1016/j.stemcr.2013.10.005

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