Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis

Familial transthyretin amyloidosis (ATTR) is an autosomal-dominant protein-folding disorder caused by over 100 distinct mutations in the transthyretin (TTR) gene. In ATTR, protein secreted from the liver aggregates and forms fibrils in target organs, chiefly the heart and peripheral nervous system,...

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Detalles Bibliográficos
Autores principales: Leung, Amy, Nah, Shirley K., Reid, Whitney, Ebata, Atsushi, Koch, Clarissa M., Monti, Stefano, Genereux, Joseph C., Wiseman, R. Luke, Wolozin, Benjamin, Connors, Lawreen H., Berk, John L., Seldin, David C., Mostoslavsky, Gustavo, Kotton, Darrell N., Murphy, George J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841264/
https://www.ncbi.nlm.nih.gov/pubmed/24286032
http://dx.doi.org/10.1016/j.stemcr.2013.10.003

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