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Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series
Weight reduction may be necessary in patients with end-stage liver disease (ESLD) before liver transplantation. Although very low calorie diets (VLCDs) are a highly effective weight loss strategy, they risk inducing protein-calorie malnutrition, sarcopenia and hepatic encephalopathy in ESLD patients...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841440/ https://www.ncbi.nlm.nih.gov/pubmed/24247485 http://dx.doi.org/10.1038/nutd.2013.36 |
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author | Temmerman, J C Friedman, A N |
author_facet | Temmerman, J C Friedman, A N |
author_sort | Temmerman, J C |
collection | PubMed |
description | Weight reduction may be necessary in patients with end-stage liver disease (ESLD) before liver transplantation. Although very low calorie diets (VLCDs) are a highly effective weight loss strategy, they risk inducing protein-calorie malnutrition, sarcopenia and hepatic encephalopathy in ESLD patients. We report for the first time on the use of VCLDs in ESLD. Two severely obese individuals with ESLD underwent a modified VLCD to become eligible for liver transplantation. Patients consumed four protein supplements and one lean meal daily, equivalent to 800 kilocalories (kcal) and were closely monitored during the diet period. Subject 1, a 46-year-old male with alcoholic cirrhosis, lost 44.1 kg after 28 weeks on a modified VLCD. Liver function and MELD (model for end-stage liver disease) scores improved and he currently does not require listing for transplantation. Subject 2, a 64-year-old female with non-alcoholic steatohepatitis, lost 39.7 kg after a 30-week modified VLCD. She is awaiting liver transplantation listing with a stable MELD score. VLCDs were well tolerated by both patients without adverse effects. In conclusion, under close medical supervision VLCDs in patients with ESLD can be safe and effective in reducing weight, facilitating liver transplantation listing, and possibly improving liver damage. |
format | Online Article Text |
id | pubmed-3841440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38414402013-11-27 Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series Temmerman, J C Friedman, A N Nutr Diabetes Short Communication Weight reduction may be necessary in patients with end-stage liver disease (ESLD) before liver transplantation. Although very low calorie diets (VLCDs) are a highly effective weight loss strategy, they risk inducing protein-calorie malnutrition, sarcopenia and hepatic encephalopathy in ESLD patients. We report for the first time on the use of VCLDs in ESLD. Two severely obese individuals with ESLD underwent a modified VLCD to become eligible for liver transplantation. Patients consumed four protein supplements and one lean meal daily, equivalent to 800 kilocalories (kcal) and were closely monitored during the diet period. Subject 1, a 46-year-old male with alcoholic cirrhosis, lost 44.1 kg after 28 weeks on a modified VLCD. Liver function and MELD (model for end-stage liver disease) scores improved and he currently does not require listing for transplantation. Subject 2, a 64-year-old female with non-alcoholic steatohepatitis, lost 39.7 kg after a 30-week modified VLCD. She is awaiting liver transplantation listing with a stable MELD score. VLCDs were well tolerated by both patients without adverse effects. In conclusion, under close medical supervision VLCDs in patients with ESLD can be safe and effective in reducing weight, facilitating liver transplantation listing, and possibly improving liver damage. Nature Publishing Group 2013-11 2013-11-18 /pmc/articles/PMC3841440/ /pubmed/24247485 http://dx.doi.org/10.1038/nutd.2013.36 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Short Communication Temmerman, J C Friedman, A N Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title | Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title_full | Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title_fullStr | Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title_full_unstemmed | Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title_short | Very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
title_sort | very low calorie ketogenic weight reduction diet in patients with cirrhosis: a case series |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841440/ https://www.ncbi.nlm.nih.gov/pubmed/24247485 http://dx.doi.org/10.1038/nutd.2013.36 |
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