Cargando…

Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4

We studied the accuracy of spot urine protein creatinine ratio (SpUr-PCR) to assess 24 h urine protein excretion (24 h-UP) in patients with chronic kidney disease (CKD). A total of 100 proteinuric CKD patients of stages 3 and 4 were studied. 24 h urine was collected to measure 24 h-UP and creatinine...

Descripción completa

Detalles Bibliográficos
Autores principales: Nayak, R., Annigeri, R. A., Vadamalai, V., Seshadri, R., Balasubramanian, S., Rao, B. S., Kowdle, P. C., Mani, M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841511/
https://www.ncbi.nlm.nih.gov/pubmed/24339521
http://dx.doi.org/10.4103/0971-4065.120340
_version_ 1782292788447019008
author Nayak, R.
Annigeri, R. A.
Vadamalai, V.
Seshadri, R.
Balasubramanian, S.
Rao, B. S.
Kowdle, P. C.
Mani, M. K.
author_facet Nayak, R.
Annigeri, R. A.
Vadamalai, V.
Seshadri, R.
Balasubramanian, S.
Rao, B. S.
Kowdle, P. C.
Mani, M. K.
author_sort Nayak, R.
collection PubMed
description We studied the accuracy of spot urine protein creatinine ratio (SpUr-PCR) to assess 24 h urine protein excretion (24 h-UP) in patients with chronic kidney disease (CKD). A total of 100 proteinuric CKD patients of stages 3 and 4 were studied. 24 h urine was collected to measure 24 h-UP and creatinine. A random day time urine sample was analyzed to measure the PCR. A formula to estimate 24 h creatinine excretion was derived from linear regression analysis and a correction factor was introduced to assess whether this improves the accuracy of the SpUr PCR in predicting 24 h-UP. Accuracy of the SpUr-PCR was assessed by Pearson's correlation, regression analysis, and Bland Altman analysis. Mean age was 51.85 ± 12 years and 81% of the patients were male. SpUr-PCR predicted 24 h-UP with good accuracy (r = 0.86 on a data transformed to a logarithmic scale, P < 0.001) and there was a good agreement between these two measures of proteinuria. However, SpUr-PCR was inaccurate in the subgroup with nephrotic range proteinuria (r = 0.35, P = 0.062), but when a correction factor for 24-h urine creatinine (24 h-UCr) was introduced, the accuracy of SpUr-PCR improved significantly in this group (r = 0.45, P = 0.013). Introduction of the correction factor improved the degree of agreement between these two measures in women, but not the correlation. Overall, SpUr-PCR accurately predicted 24 h-UP. Adding a correction factor for 24 h-UCr improved correlation in the subgroup of patients with the nephrotic range proteinuria and the degree of agreement in female patients, and hence may be used in expressing proteinuria measured by SpUr-PCR to improve its accuracy in them.
format Online
Article
Text
id pubmed-3841511
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-38415112013-12-11 Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4 Nayak, R. Annigeri, R. A. Vadamalai, V. Seshadri, R. Balasubramanian, S. Rao, B. S. Kowdle, P. C. Mani, M. K. Indian J Nephrol Original Article We studied the accuracy of spot urine protein creatinine ratio (SpUr-PCR) to assess 24 h urine protein excretion (24 h-UP) in patients with chronic kidney disease (CKD). A total of 100 proteinuric CKD patients of stages 3 and 4 were studied. 24 h urine was collected to measure 24 h-UP and creatinine. A random day time urine sample was analyzed to measure the PCR. A formula to estimate 24 h creatinine excretion was derived from linear regression analysis and a correction factor was introduced to assess whether this improves the accuracy of the SpUr PCR in predicting 24 h-UP. Accuracy of the SpUr-PCR was assessed by Pearson's correlation, regression analysis, and Bland Altman analysis. Mean age was 51.85 ± 12 years and 81% of the patients were male. SpUr-PCR predicted 24 h-UP with good accuracy (r = 0.86 on a data transformed to a logarithmic scale, P < 0.001) and there was a good agreement between these two measures of proteinuria. However, SpUr-PCR was inaccurate in the subgroup with nephrotic range proteinuria (r = 0.35, P = 0.062), but when a correction factor for 24-h urine creatinine (24 h-UCr) was introduced, the accuracy of SpUr-PCR improved significantly in this group (r = 0.45, P = 0.013). Introduction of the correction factor improved the degree of agreement between these two measures in women, but not the correlation. Overall, SpUr-PCR accurately predicted 24 h-UP. Adding a correction factor for 24 h-UCr improved correlation in the subgroup of patients with the nephrotic range proteinuria and the degree of agreement in female patients, and hence may be used in expressing proteinuria measured by SpUr-PCR to improve its accuracy in them. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3841511/ /pubmed/24339521 http://dx.doi.org/10.4103/0971-4065.120340 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nayak, R.
Annigeri, R. A.
Vadamalai, V.
Seshadri, R.
Balasubramanian, S.
Rao, B. S.
Kowdle, P. C.
Mani, M. K.
Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title_full Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title_fullStr Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title_full_unstemmed Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title_short Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
title_sort accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841511/
https://www.ncbi.nlm.nih.gov/pubmed/24339521
http://dx.doi.org/10.4103/0971-4065.120340
work_keys_str_mv AT nayakr accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT annigerira accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT vadamalaiv accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT seshadrir accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT balasubramanians accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT raobs accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT kowdlepc accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4
AT manimk accuracyofspoturineproteincreatinineratioinmeasuringproteinuriainchronickidneydiseasestage3and4