Using human induced pluripotent stem cells to treat retinal disease()

The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art labora...

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Detalles Bibliográficos
Autores principales: Borooah, S., Phillips, M.J., Bilican, B., Wright, A.F., Wilmut, I., Chandran, S., Gamm, D., Dhillon, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841575/
https://www.ncbi.nlm.nih.gov/pubmed/24104210
http://dx.doi.org/10.1016/j.preteyeres.2013.09.002
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author Borooah, S.
Phillips, M.J.
Bilican, B.
Wright, A.F.
Wilmut, I.
Chandran, S.
Gamm, D.
Dhillon, B.
author_facet Borooah, S.
Phillips, M.J.
Bilican, B.
Wright, A.F.
Wilmut, I.
Chandran, S.
Gamm, D.
Dhillon, B.
author_sort Borooah, S.
collection PubMed
description The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.
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spelling pubmed-38415752013-11-27 Using human induced pluripotent stem cells to treat retinal disease() Borooah, S. Phillips, M.J. Bilican, B. Wright, A.F. Wilmut, I. Chandran, S. Gamm, D. Dhillon, B. Prog Retin Eye Res Article The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease. Pergamon 2013-11 /pmc/articles/PMC3841575/ /pubmed/24104210 http://dx.doi.org/10.1016/j.preteyeres.2013.09.002 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Borooah, S.
Phillips, M.J.
Bilican, B.
Wright, A.F.
Wilmut, I.
Chandran, S.
Gamm, D.
Dhillon, B.
Using human induced pluripotent stem cells to treat retinal disease()
title Using human induced pluripotent stem cells to treat retinal disease()
title_full Using human induced pluripotent stem cells to treat retinal disease()
title_fullStr Using human induced pluripotent stem cells to treat retinal disease()
title_full_unstemmed Using human induced pluripotent stem cells to treat retinal disease()
title_short Using human induced pluripotent stem cells to treat retinal disease()
title_sort using human induced pluripotent stem cells to treat retinal disease()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841575/
https://www.ncbi.nlm.nih.gov/pubmed/24104210
http://dx.doi.org/10.1016/j.preteyeres.2013.09.002
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