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Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease

BACKGROUND: Several studies have demonstrated considerable impairment of quality of life (QOL) in obstructive sleep apnea (OSA) patients, but its relation with severity of OSA is yet unclear. STUDY OBJECTIVES: To investigate the effects of OSA on the QOL and its association with the disease severity...

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Autores principales: Dutt, Naveen, Janmeja, Ashok Kumar, Mohapatra, Prasanta Raghab, Singh, Anup Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841684/
https://www.ncbi.nlm.nih.gov/pubmed/24339485
http://dx.doi.org/10.4103/0970-2113.120603
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author Dutt, Naveen
Janmeja, Ashok Kumar
Mohapatra, Prasanta Raghab
Singh, Anup Kumar
author_facet Dutt, Naveen
Janmeja, Ashok Kumar
Mohapatra, Prasanta Raghab
Singh, Anup Kumar
author_sort Dutt, Naveen
collection PubMed
description BACKGROUND: Several studies have demonstrated considerable impairment of quality of life (QOL) in obstructive sleep apnea (OSA) patients, but its relation with severity of OSA is yet unclear. STUDY OBJECTIVES: To investigate the effects of OSA on the QOL and its association with the disease severity. DESIGN AND SETTING: Observational, prospective case-control study. MATERIALS AND METHODS: QOL of 69 OSA patients and 41 healthy controls were assessed using the Calgary sleep apnea quality of life index (SAQLI) on the morning following the polysomnography (PSG) study. STATISTICS: All statistical analyses were performed using the SPSS 17.0 (SPSS Inc., Chicago). Differences between sleep-related symptoms and SAQLI subscales scores were assessed with the Chi-square test and the Student t-test. Due to non-normal distribution, differences between SAQLI scores of controls and OSA patients were evaluated using a non-parametric Mann-Whitney test. Spearman correlation and backward multiple regression analysis were used to analyze the association between SAQLI scores and sleep indices and anthropometric variables and PSG variables. RESULTS: Study included 69 cases (57 male and 12 females) with a mean age, weight, height, neck circumference, and body mass index 48.45 ± 10.12 years, 83.03 ± 16.48 kg, 159.75 ± 28.29 cm, 44.01 ± 3.23 cm and 30.77 ± 6.71 kg/m(2). Mean apnea-hypopnea index was 26.39 ± 16.62. The median score of four SAQLI domains daily function, social interaction, emotional, symptoms and total mean SAQLI score were 3.64 (3.46-3.90), 3.77 (3.51-3.88), 3.64 (3.53-3.83), 4.80 (4.68-5.11), 4.09 (3.88-4.09),and 1.36 (1.29-1.71), 1.38 (1.24-1.62), 1.45 (1.23-1.62), 2.00 (1.78-2.26), 1.55 (1.46-1.73) for patients and controls respectively. All the individual domain scores and the mean SAQLI scores of patients were significantly higher than the controls. CONCLUSION: OSA causes significant impairment of QOL, but the severity of impairment is not directly proportional to the severity of OSA.
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spelling pubmed-38416842013-12-11 Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease Dutt, Naveen Janmeja, Ashok Kumar Mohapatra, Prasanta Raghab Singh, Anup Kumar Lung India Original Article BACKGROUND: Several studies have demonstrated considerable impairment of quality of life (QOL) in obstructive sleep apnea (OSA) patients, but its relation with severity of OSA is yet unclear. STUDY OBJECTIVES: To investigate the effects of OSA on the QOL and its association with the disease severity. DESIGN AND SETTING: Observational, prospective case-control study. MATERIALS AND METHODS: QOL of 69 OSA patients and 41 healthy controls were assessed using the Calgary sleep apnea quality of life index (SAQLI) on the morning following the polysomnography (PSG) study. STATISTICS: All statistical analyses were performed using the SPSS 17.0 (SPSS Inc., Chicago). Differences between sleep-related symptoms and SAQLI subscales scores were assessed with the Chi-square test and the Student t-test. Due to non-normal distribution, differences between SAQLI scores of controls and OSA patients were evaluated using a non-parametric Mann-Whitney test. Spearman correlation and backward multiple regression analysis were used to analyze the association between SAQLI scores and sleep indices and anthropometric variables and PSG variables. RESULTS: Study included 69 cases (57 male and 12 females) with a mean age, weight, height, neck circumference, and body mass index 48.45 ± 10.12 years, 83.03 ± 16.48 kg, 159.75 ± 28.29 cm, 44.01 ± 3.23 cm and 30.77 ± 6.71 kg/m(2). Mean apnea-hypopnea index was 26.39 ± 16.62. The median score of four SAQLI domains daily function, social interaction, emotional, symptoms and total mean SAQLI score were 3.64 (3.46-3.90), 3.77 (3.51-3.88), 3.64 (3.53-3.83), 4.80 (4.68-5.11), 4.09 (3.88-4.09),and 1.36 (1.29-1.71), 1.38 (1.24-1.62), 1.45 (1.23-1.62), 2.00 (1.78-2.26), 1.55 (1.46-1.73) for patients and controls respectively. All the individual domain scores and the mean SAQLI scores of patients were significantly higher than the controls. CONCLUSION: OSA causes significant impairment of QOL, but the severity of impairment is not directly proportional to the severity of OSA. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3841684/ /pubmed/24339485 http://dx.doi.org/10.4103/0970-2113.120603 Text en Copyright: © Lung India http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dutt, Naveen
Janmeja, Ashok Kumar
Mohapatra, Prasanta Raghab
Singh, Anup Kumar
Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title_full Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title_fullStr Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title_full_unstemmed Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title_short Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
title_sort quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841684/
https://www.ncbi.nlm.nih.gov/pubmed/24339485
http://dx.doi.org/10.4103/0970-2113.120603
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