Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

V(D)J joining is mediated by RAG recombinase during early B-lymphocyte development in the bone marrow (BM). Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoid structures. Previous studies questioned the strict ontological partitioning of these processes....

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Satyendra, Wuerffel, Robert, Achour, Ikbel, Lajoie, Bryan, Sen, Ranjan, Dekker, Job, Feeney, Ann J., Kenter, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841733/
https://www.ncbi.nlm.nih.gov/pubmed/24240234
http://dx.doi.org/10.1101/gad.227165.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841733/
https://www.ncbi.nlm.nih.gov/pubmed/24240234
http://dx.doi.org/10.1101/gad.227165.113

Ejemplares similares