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Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids
Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its act...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841998/ https://www.ncbi.nlm.nih.gov/pubmed/24347928 http://dx.doi.org/10.4103/0973-7847.120524 |
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author | Moloudizargari, Milad Mikaili, Peyman Aghajanshakeri, Shahin Asghari, Mohammad Hossein Shayegh, Jalal |
author_facet | Moloudizargari, Milad Mikaili, Peyman Aghajanshakeri, Shahin Asghari, Mohammad Hossein Shayegh, Jalal |
author_sort | Moloudizargari, Milad |
collection | PubMed |
description | Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. Analytical studies on the chemical composition of the plant show that the most important constituents of this plant are beta-carboline alkaloids such as harmalol, harmaline, and harmine. Harmine is the most studied among these naturally occurring alkaloids. In addition to P. harmala (Syrian rue), these beta-carbolines are present in many other plants such as Banisteria caapi and are used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala (Syrian rue). |
format | Online Article Text |
id | pubmed-3841998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38419982013-12-13 Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids Moloudizargari, Milad Mikaili, Peyman Aghajanshakeri, Shahin Asghari, Mohammad Hossein Shayegh, Jalal Pharmacogn Rev Plant Review Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. Analytical studies on the chemical composition of the plant show that the most important constituents of this plant are beta-carboline alkaloids such as harmalol, harmaline, and harmine. Harmine is the most studied among these naturally occurring alkaloids. In addition to P. harmala (Syrian rue), these beta-carbolines are present in many other plants such as Banisteria caapi and are used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala (Syrian rue). Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3841998/ /pubmed/24347928 http://dx.doi.org/10.4103/0973-7847.120524 Text en Copyright: © Pharmacognosy Reviews http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Plant Review Moloudizargari, Milad Mikaili, Peyman Aghajanshakeri, Shahin Asghari, Mohammad Hossein Shayegh, Jalal Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title | Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title_full | Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title_fullStr | Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title_full_unstemmed | Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title_short | Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |
title_sort | pharmacological and therapeutic effects of peganum harmala and its main alkaloids |
topic | Plant Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841998/ https://www.ncbi.nlm.nih.gov/pubmed/24347928 http://dx.doi.org/10.4103/0973-7847.120524 |
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