Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells

The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate th...

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Detalles Bibliográficos
Autores principales: Jiménez-Periáñez, A., Abos Gracia, B., López Relaño, J., Diez-Rivero, C. M., Reche, P. A., Martínez-Naves, E., Matveyeva, E., Gómez del Moral, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842076/
https://www.ncbi.nlm.nih.gov/pubmed/24324504
http://dx.doi.org/10.1155/2013/362163
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author Jiménez-Periáñez, A.
Abos Gracia, B.
López Relaño, J.
Diez-Rivero, C. M.
Reche, P. A.
Martínez-Naves, E.
Matveyeva, E.
Gómez del Moral, M.
author_facet Jiménez-Periáñez, A.
Abos Gracia, B.
López Relaño, J.
Diez-Rivero, C. M.
Reche, P. A.
Martínez-Naves, E.
Matveyeva, E.
Gómez del Moral, M.
author_sort Jiménez-Periáñez, A.
collection PubMed
description The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.
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spelling pubmed-38420762013-12-09 Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells Jiménez-Periáñez, A. Abos Gracia, B. López Relaño, J. Diez-Rivero, C. M. Reche, P. A. Martínez-Naves, E. Matveyeva, E. Gómez del Moral, M. Clin Dev Immunol Research Article The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes. Hindawi Publishing Corporation 2013 2013-11-10 /pmc/articles/PMC3842076/ /pubmed/24324504 http://dx.doi.org/10.1155/2013/362163 Text en Copyright © 2013 A. Jiménez-Periáñez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiménez-Periáñez, A.
Abos Gracia, B.
López Relaño, J.
Diez-Rivero, C. M.
Reche, P. A.
Martínez-Naves, E.
Matveyeva, E.
Gómez del Moral, M.
Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title_full Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title_fullStr Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title_full_unstemmed Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title_short Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
title_sort mesoporous silicon microparticles enhance mhc class i cross-antigen presentation by human dendritic cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842076/
https://www.ncbi.nlm.nih.gov/pubmed/24324504
http://dx.doi.org/10.1155/2013/362163
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