Cargando…

Conditional Dicer Substrate Formation via Shape and Sequence Transduction with Small Conditional RNAs

[Image: see text] RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) enables knockdown of a gene of choice, executing the logical operation: silence gene Y. The fact that the siRNA is constitutively active is a significant limitation, making it difficult to confine knockdown to a sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Hochrein, Lisa M., Schwarzkopf, Maayan, Shahgholi, Mona, Yin, Peng, Pierce, Niles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842090/
https://www.ncbi.nlm.nih.gov/pubmed/24219616
http://dx.doi.org/10.1021/ja404676x