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Duloxetine in panic disorder with somatic gastric pain

Panic disorder is the most common type of anxiety disorder, and its most common expression is panic attacks characterized with sudden attacks of anxiety with numerous symptoms, including palpitations, tachycardia, tachypnea, nausea, and vertigo: ie, cardiovascular, gastroenterologic, respiratory, an...

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Autores principales: Preve, Matteo, Nisita, Cristiana, Bellini, Massimo, Dell’Osso, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842215/
https://www.ncbi.nlm.nih.gov/pubmed/24294001
http://dx.doi.org/10.2147/NDT.S35922
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author Preve, Matteo
Nisita, Cristiana
Bellini, Massimo
Dell’Osso, Liliana
author_facet Preve, Matteo
Nisita, Cristiana
Bellini, Massimo
Dell’Osso, Liliana
author_sort Preve, Matteo
collection PubMed
description Panic disorder is the most common type of anxiety disorder, and its most common expression is panic attacks characterized with sudden attacks of anxiety with numerous symptoms, including palpitations, tachycardia, tachypnea, nausea, and vertigo: ie, cardiovascular, gastroenterologic, respiratory, and neuro-otologic symptoms. In clinical practice, panic disorder manifests with isolated gastroenteric or cardiovascular symptoms, requiring additional clinical visits after psychiatric intervention. The first-line treatment for anxiety disorders, and in particular for panic disorder, is the selective serotonin reuptake inhibitors. However, these drugs can have adverse effects, including sexual dysfunction, increased bodyweight, and abnormal bleeding, that may be problematic for some patients. Here we report the case of a 29-year-old Caucasian woman affected by panic disorder with agoraphobia who was referred to our clinic for recurrent gastroenteric panic symptoms. The patient reported improvement in her anxiety symptoms and panic attacks while on a selective serotonin reuptake inhibitor, but not in her gastric somatic problems, so the decision was taken to start her on duloxetine, a serotonin-norepinephrine reuptake inhibitor. After 6 months of treatment, the patient achieved complete remission of her gastric and panic-related symptoms, and was able to stop triple gastric therapy. Other authors have hypothesized and confirmed that duloxetine has greater initial noradrenergic effects than venlafaxine and is effective in patients with panic disorder. This case report underscores the possibility of tailoring therapeutic strategies for the gastroenteric expression of panic disorder.
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spelling pubmed-38422152013-11-29 Duloxetine in panic disorder with somatic gastric pain Preve, Matteo Nisita, Cristiana Bellini, Massimo Dell’Osso, Liliana Neuropsychiatr Dis Treat Case Report Panic disorder is the most common type of anxiety disorder, and its most common expression is panic attacks characterized with sudden attacks of anxiety with numerous symptoms, including palpitations, tachycardia, tachypnea, nausea, and vertigo: ie, cardiovascular, gastroenterologic, respiratory, and neuro-otologic symptoms. In clinical practice, panic disorder manifests with isolated gastroenteric or cardiovascular symptoms, requiring additional clinical visits after psychiatric intervention. The first-line treatment for anxiety disorders, and in particular for panic disorder, is the selective serotonin reuptake inhibitors. However, these drugs can have adverse effects, including sexual dysfunction, increased bodyweight, and abnormal bleeding, that may be problematic for some patients. Here we report the case of a 29-year-old Caucasian woman affected by panic disorder with agoraphobia who was referred to our clinic for recurrent gastroenteric panic symptoms. The patient reported improvement in her anxiety symptoms and panic attacks while on a selective serotonin reuptake inhibitor, but not in her gastric somatic problems, so the decision was taken to start her on duloxetine, a serotonin-norepinephrine reuptake inhibitor. After 6 months of treatment, the patient achieved complete remission of her gastric and panic-related symptoms, and was able to stop triple gastric therapy. Other authors have hypothesized and confirmed that duloxetine has greater initial noradrenergic effects than venlafaxine and is effective in patients with panic disorder. This case report underscores the possibility of tailoring therapeutic strategies for the gastroenteric expression of panic disorder. Dove Medical Press 2013 2013-11-21 /pmc/articles/PMC3842215/ /pubmed/24294001 http://dx.doi.org/10.2147/NDT.S35922 Text en © 2013 Preve et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Preve, Matteo
Nisita, Cristiana
Bellini, Massimo
Dell’Osso, Liliana
Duloxetine in panic disorder with somatic gastric pain
title Duloxetine in panic disorder with somatic gastric pain
title_full Duloxetine in panic disorder with somatic gastric pain
title_fullStr Duloxetine in panic disorder with somatic gastric pain
title_full_unstemmed Duloxetine in panic disorder with somatic gastric pain
title_short Duloxetine in panic disorder with somatic gastric pain
title_sort duloxetine in panic disorder with somatic gastric pain
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842215/
https://www.ncbi.nlm.nih.gov/pubmed/24294001
http://dx.doi.org/10.2147/NDT.S35922
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