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In the Absence of Effector Proteins, the Pseudomonas aeruginosa Type Three Secretion System Needle Tip Complex Contributes to Lung Injury and Systemic Inflammatory Responses
Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung endothelial injury. We first established a model in which P. aeruginosa wild type strain PA103 caused pneumonia-induced sepsis and distal organ dys...
Autores principales: | Audia, Jonathon P., Lindsey, Ashley S., Housley, Nicole A., Ochoa, Courtney R., Zhou, Chun, Toba, Michie, Oka, Masahiko, Annamdevula, Naga S., Fitzgerald, Meshann S., Frank, Dara W., Alvarez, Diego F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842252/ https://www.ncbi.nlm.nih.gov/pubmed/24312357 http://dx.doi.org/10.1371/journal.pone.0081792 |
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