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Biopterin Metabolism and eNOS Expression during Hypoxic Pulmonary Hypertension in Mice

Tetrahydrobiopterin (BH(4)), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified models demonstrate that BH(4) pulmonary deficiency is a key determinant in t...

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Detalles Bibliográficos
Autores principales:	Dubois, Mathilde, Delannoy, Estelle, Duluc, Lucie, Closs, Ellen, Li, Huige, Toussaint, Christian, Gadeau, Alain-Pierre, Gödecke, Axel, Freund-Michel, Véronique, Courtois, Arnaud, Marthan, Roger, Savineau, Jean-Pierre, Muller, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842263/ https://www.ncbi.nlm.nih.gov/pubmed/24312428 http://dx.doi.org/10.1371/journal.pone.0082594

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