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Branched Chain Amino Acid Suppresses Hepatocellular Cancer Stem Cells through the Activation of Mammalian Target of Rapamycin

Differentiation of cancer stem cells (CSCs) into cancer cells causes increased sensitivity to chemotherapeutic agents. Although inhibition of mammalian target of rapamycin (mTOR) leads to CSC survival, the effect of branched chain amino acids (BCAAs), an mTOR complex 1 (mTORC1) activator remains unk...

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Detalles Bibliográficos
Autores principales:	Nishitani, Shinobu, Horie, Mayumi, Ishizaki, Sonoko, Yano, Hirohisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842306/ https://www.ncbi.nlm.nih.gov/pubmed/24312415 http://dx.doi.org/10.1371/journal.pone.0082346

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