Cargando…

Mammalian Target of Rapamycin Complex 2 (mTORC2) Is a Critical Determinant of Bladder Cancer Invasion

Bladder cancer is the fourth most common cause of cancer in males in the United States. Invasive behavior is a major determinant of prognosis. In this study, we identified mammalian target of rapamycin complex 2 (mTORC2) as a central regulator of bladder cancer cell migration and invasion. mTORC2 ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Sounak, Hau, Andrew M., Beach, Jordan R., Harwalker, Jyoti, Mantuano, Elisabetta, Gonias, Steven L., Egelhoff, Thomas T., Hansel, Donna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842329/ https://www.ncbi.nlm.nih.gov/pubmed/24312263 http://dx.doi.org/10.1371/journal.pone.0081081

Ejemplares similares

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
por: Delgoffe, Greg M., et al.
Publicado: (2011)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)
por: Demirkan, Gokhan, et al.
Publicado: (2011)

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
por: Wang, Chen, et al.
Publicado: (2014)

Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2
por: Wang, Weijie, et al.
Publicado: (2014)

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
por: Abdallah, Chadi G., et al.
Publicado: (2020)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
por: Ye, Lan, et al.
Publicado: (2012)

The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
por: Yoon, Mee-Sup, et al.
Publicado: (2016)

Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids
por: Zheng, Xu, et al.
Publicado: (2014)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling
por: Kusch, Angelika, et al.
Publicado: (2015)

Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy
por: Huan, Jianya, et al.
Publicado: (2022)

A novel rapamycin analog is highly selective for mTORC1 in vivo
por: Schreiber, Katherine H., et al.
Publicado: (2019)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Crosstalk between Edc4 and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in mRNA Decapping
por: Rahman, Hazir, et al.
Publicado: (2014)

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
por: Schreiber, Katherine H, et al.
Publicado: (2015)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
por: Xie, Jianling, et al.
Publicado: (2011)

Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
por: Razmara, Masoud, et al.
Publicado: (2018)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts
por: Groenewoud, Marlous J., et al.
Publicado: (2013)

Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation
por: MUROKAWA, Hiroka, et al.
Publicado: (2023)

Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
por: Yao, Yao, et al.
Publicado: (2017)

T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca(2+)Production
por: Wang, Ji, et al.
Publicado: (2018)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
por: Barlow, A. D., et al.
Publicado: (2012)

Towards specific inhibition of mTORC2
por: Murray, Elizabeth R., et al.
Publicado: (2017)

Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear
por: Workman, Jason J, et al.
Publicado: (2014)

Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
por: Hujber, Zoltán, et al.
Publicado: (2017)

Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts
por: Wang, Weipeng, et al.
Publicado: (2015)

mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine
por: Alam, Mahabub, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e21khf6occhtus57abq511nm00