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Testing the Reproducibility of Multiple Displacement Amplification on Genomes of Clonal Endosymbiont Populations
The multiple displacement amplification method has revolutionized genomic studies of uncultured bacteria, where the extraction of pure DNA in sufficient quantity for next-generation sequencing is challenging. However, the method is problematic in that it amplifies the target DNA unevenly, induces th...
Autores principales: | Ellegaard, Kirsten Maren, Klasson, Lisa, Andersson, Siv G. E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842359/ https://www.ncbi.nlm.nih.gov/pubmed/24312412 http://dx.doi.org/10.1371/journal.pone.0082319 |
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