Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()

Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be...

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Autores principales: Rami-Mark, Christina, Ungersboeck, Johanna, Haeusler, Daniela, Nics, Lukas, Philippe, Cecile, Mitterhauser, Markus, Willeit, Matthaeus, Lanzenberger, Rupert, Karanikas, Georgios, Wadsak, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842501/
https://www.ncbi.nlm.nih.gov/pubmed/23974301
http://dx.doi.org/10.1016/j.apradiso.2013.07.023
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author Rami-Mark, Christina
Ungersboeck, Johanna
Haeusler, Daniela
Nics, Lukas
Philippe, Cecile
Mitterhauser, Markus
Willeit, Matthaeus
Lanzenberger, Rupert
Karanikas, Georgios
Wadsak, Wolfgang
author_facet Rami-Mark, Christina
Ungersboeck, Johanna
Haeusler, Daniela
Nics, Lukas
Philippe, Cecile
Mitterhauser, Markus
Willeit, Matthaeus
Lanzenberger, Rupert
Karanikas, Georgios
Wadsak, Wolfgang
author_sort Rami-Mark, Christina
collection PubMed
description Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.
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spelling pubmed-38425012013-12-02 Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO() Rami-Mark, Christina Ungersboeck, Johanna Haeusler, Daniela Nics, Lukas Philippe, Cecile Mitterhauser, Markus Willeit, Matthaeus Lanzenberger, Rupert Karanikas, Georgios Wadsak, Wolfgang Appl Radiat Isot Article Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome. Pergamon Press 2013-12 /pmc/articles/PMC3842501/ /pubmed/23974301 http://dx.doi.org/10.1016/j.apradiso.2013.07.023 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Rami-Mark, Christina
Ungersboeck, Johanna
Haeusler, Daniela
Nics, Lukas
Philippe, Cecile
Mitterhauser, Markus
Willeit, Matthaeus
Lanzenberger, Rupert
Karanikas, Georgios
Wadsak, Wolfgang
Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title_full Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title_fullStr Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title_full_unstemmed Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title_short Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()
title_sort reliable set-up for in-loop (11)c-carboxylations using grignard reactions for the preparation of [carbonyl-(11)c]way-100635 and [(11)c]-(+)-phno()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842501/
https://www.ncbi.nlm.nih.gov/pubmed/23974301
http://dx.doi.org/10.1016/j.apradiso.2013.07.023
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