Cargando…

Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran

BACKGROUNDS: Normal or elevated values of serum alanine aminotransferase level (ALT) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome prevalence. OBJECTIVES: To...

Descripción completa

Detalles Bibliográficos
Autores principales: Kabir, Ali, Pourshams, Akram, Khoshnia, Masoud, Malekzadeh, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842514/
https://www.ncbi.nlm.nih.gov/pubmed/24348633
http://dx.doi.org/10.5812/hepatmon.10640
_version_ 1782292936584593408
author Kabir, Ali
Pourshams, Akram
Khoshnia, Masoud
Malekzadeh, Fatemeh
author_facet Kabir, Ali
Pourshams, Akram
Khoshnia, Masoud
Malekzadeh, Fatemeh
author_sort Kabir, Ali
collection PubMed
description BACKGROUNDS: Normal or elevated values of serum alanine aminotransferase level (ALT) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome prevalence. OBJECTIVES: To measure upper normal limit (UNL) for serum ALT in an apparently healthy Iranian old population (which we had not sufficient data before this study), and its modulating factors. PATIENTS AND METHODS: All inhabitants (> 50 years old) of Kalaleh, Golestan, Iran (N = 1986) were invited to the study. ALT measurements were performed for all subjects using the same laboratory method. Upper limit of normal (ULN) ALT was calculated based on its 95th percentile in normal weight subjects. Modulating factors of ALT were determined by multivariate analysis. RESULTS: A total of 1309 subjects, with the mean age of 61.5 ± 7.5 years were included. UNL of ALT was 18.8 U/L and 21.4 U/L in women and men, respectively. Based on univariate analysis, waist circumference (r = 0.124, P = 0.01), body mass index (r = 0.118, P = 0.01), triglyceride (r = 0.143, P = 0.01), and having metabolic syndrome (OR = 2.04) modulate ALT levels in men. Also triglyceride (r = 0.119, P = 0.01) modulates ALT levels in women. CONCLUSIONS: The calculated level for UNL of ALT is considerably far lower than previous accepted value. Age, gender, ethnicity, and metabolic factors should be accounted in future studies to determine normal ALT level.
format Online
Article
Text
id pubmed-3842514
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Kowsar
record_format MEDLINE/PubMed
spelling pubmed-38425142013-12-12 Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran Kabir, Ali Pourshams, Akram Khoshnia, Masoud Malekzadeh, Fatemeh Hepat Mon Research Article BACKGROUNDS: Normal or elevated values of serum alanine aminotransferase level (ALT) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome prevalence. OBJECTIVES: To measure upper normal limit (UNL) for serum ALT in an apparently healthy Iranian old population (which we had not sufficient data before this study), and its modulating factors. PATIENTS AND METHODS: All inhabitants (> 50 years old) of Kalaleh, Golestan, Iran (N = 1986) were invited to the study. ALT measurements were performed for all subjects using the same laboratory method. Upper limit of normal (ULN) ALT was calculated based on its 95th percentile in normal weight subjects. Modulating factors of ALT were determined by multivariate analysis. RESULTS: A total of 1309 subjects, with the mean age of 61.5 ± 7.5 years were included. UNL of ALT was 18.8 U/L and 21.4 U/L in women and men, respectively. Based on univariate analysis, waist circumference (r = 0.124, P = 0.01), body mass index (r = 0.118, P = 0.01), triglyceride (r = 0.143, P = 0.01), and having metabolic syndrome (OR = 2.04) modulate ALT levels in men. Also triglyceride (r = 0.119, P = 0.01) modulates ALT levels in women. CONCLUSIONS: The calculated level for UNL of ALT is considerably far lower than previous accepted value. Age, gender, ethnicity, and metabolic factors should be accounted in future studies to determine normal ALT level. Kowsar 2013-10-20 /pmc/articles/PMC3842514/ /pubmed/24348633 http://dx.doi.org/10.5812/hepatmon.10640 Text en Copyright © 2013, Kowsar Corp. http://creativecommons.org/licenses/by/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kabir, Ali
Pourshams, Akram
Khoshnia, Masoud
Malekzadeh, Fatemeh
Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title_full Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title_fullStr Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title_full_unstemmed Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title_short Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran
title_sort normal limit for serum alanine aminotransferase level and distribution of metabolic factors in old population of kalaleh, iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842514/
https://www.ncbi.nlm.nih.gov/pubmed/24348633
http://dx.doi.org/10.5812/hepatmon.10640
work_keys_str_mv AT kabirali normallimitforserumalanineaminotransferaselevelanddistributionofmetabolicfactorsinoldpopulationofkalalehiran
AT pourshamsakram normallimitforserumalanineaminotransferaselevelanddistributionofmetabolicfactorsinoldpopulationofkalalehiran
AT khoshniamasoud normallimitforserumalanineaminotransferaselevelanddistributionofmetabolicfactorsinoldpopulationofkalalehiran
AT malekzadehfatemeh normallimitforserumalanineaminotransferaselevelanddistributionofmetabolicfactorsinoldpopulationofkalalehiran