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Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction?
The classical etiology of erectile dysfunction (ED) comprises aging and vascular, neurogenic, psychological and hormonal components. Recent studies have shown that ED can be the forerunner of serious cardiovascular disturbances. It has also been reported that peripheral neuropathy and microvascular...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842553/ https://www.ncbi.nlm.nih.gov/pubmed/24350081 http://dx.doi.org/10.5812/numonthly.11523 |
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author | Celik, Orcun Yücel, Selcuk |
author_facet | Celik, Orcun Yücel, Selcuk |
author_sort | Celik, Orcun |
collection | PubMed |
description | The classical etiology of erectile dysfunction (ED) comprises aging and vascular, neurogenic, psychological and hormonal components. Recent studies have shown that ED can be the forerunner of serious cardiovascular disturbances. It has also been reported that peripheral neuropathy and microvascular injuries caused by pathophysiological changes in patients with diabetes and obesity lead to ED in a significant number of such cases. These patients develop clinically significant ED and comprise a significant portion of the patient group which do not respond to PDE-5 inhibitors. Testosterone has been shown to increase the expression of PDE-5. This function of testosterone supports its effect on the regulation of erection and increasing the sexual libido. In view of the complexity of ED, as well as the effect of testosterone on erection, it is concluded that PDE-5 inhibitors in combination with testosterone replacement would be a better therapy alternative in the management of erectile dysfunction in hypogonadal patients. |
format | Online Article Text |
id | pubmed-3842553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-38425532013-12-12 Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? Celik, Orcun Yücel, Selcuk Nephrourol Mon Review Article The classical etiology of erectile dysfunction (ED) comprises aging and vascular, neurogenic, psychological and hormonal components. Recent studies have shown that ED can be the forerunner of serious cardiovascular disturbances. It has also been reported that peripheral neuropathy and microvascular injuries caused by pathophysiological changes in patients with diabetes and obesity lead to ED in a significant number of such cases. These patients develop clinically significant ED and comprise a significant portion of the patient group which do not respond to PDE-5 inhibitors. Testosterone has been shown to increase the expression of PDE-5. This function of testosterone supports its effect on the regulation of erection and increasing the sexual libido. In view of the complexity of ED, as well as the effect of testosterone on erection, it is concluded that PDE-5 inhibitors in combination with testosterone replacement would be a better therapy alternative in the management of erectile dysfunction in hypogonadal patients. Kowsar 2013-07-29 2013-09 /pmc/articles/PMC3842553/ /pubmed/24350081 http://dx.doi.org/10.5812/numonthly.11523 Text en Copyright © 2013, Nephrology and Urology Research Center http://creativecommons.org/licenses/by/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Celik, Orcun Yücel, Selcuk Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title | Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title_full | Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title_fullStr | Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title_full_unstemmed | Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title_short | Testosterone Replacement Therapy: Should It Be Performed in Erectile Dysfunction? |
title_sort | testosterone replacement therapy: should it be performed in erectile dysfunction? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842553/ https://www.ncbi.nlm.nih.gov/pubmed/24350081 http://dx.doi.org/10.5812/numonthly.11523 |
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