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Samhd1 knockout mice: modeling retrovirus restriction in vivo
The host dNTP hydrolase SAMHD1 acts as a viral restriction factor to inhibit the replication of several retroviruses and DNA viruses in non-cycling human immune cells. However, understanding the physiological role of mammalian SAMHD1 has been elusive due to the lack of an animal model. Two recent st...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842632/ https://www.ncbi.nlm.nih.gov/pubmed/24257155 http://dx.doi.org/10.1186/1742-4690-10-142 |