Cargando…

Effective visualization of integrated knowledge and data to enable informed decisions in drug development and translational medicine

Integrative understanding of preclinical and clinical data is imperative to enable informed decisions and reduce the attrition rate during drug development. The volume and variety of data generated during drug development have increased tremendously. A new information model and visualization tool wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brynne, Lena, Bresell, Anders, Sjögren, Niclas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842641/ https://www.ncbi.nlm.nih.gov/pubmed/24098919 http://dx.doi.org/10.1186/1479-5876-11-250

Ejemplares similares

Effective knowledge management in translational medicine
por: Szalma, Sándor, et al.
Publicado: (2010)

Knowledge translation strategies to improve the use of evidence in public health decision making in local government: intervention design and implementation plan
por: Armstrong, Rebecca, et al.
Publicado: (2013)

Health equity: evidence synthesis and knowledge translation methods
por: Welch, Vivian A, et al.
Publicado: (2013)

Facilitating knowledge transfer: decision support tools in environment and health
por: Liu, Hai-Ying, et al.
Publicado: (2012)

Semantics-based plausible reasoning to extend the knowledge coverage of medical knowledge bases for improved clinical decision support
por: Mohammadhassanzadeh, Hossein, et al.
Publicado: (2017)

Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples
por: Noberini, Roberta, et al.
Publicado: (2021)

Engaging with patients in research on knowledge translation/implementation science methods: a self study
por: MacLeod, Martha L. P., et al.
Publicado: (2022)

PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison
por: Monnin, Pierre, et al.
Publicado: (2019)

From biobank and data silos into a data commons: convergence to support translational medicine
por: Asiimwe, Rebecca, et al.
Publicado: (2021)

Closing the Loop: Facilitating the Use of Autopsy Information in Medical Decision Making and Managed Care
por: Nemetz, Peter N.
Publicado: (2008)

Breastfeeding, pregnancy, medicines, neurodevelopment, and population databases: the information desert
por: Jordan, Sue, et al.
Publicado: (2022)

Exploiting large-scale drug-protein interaction information for computational drug repurposing
por: Liu, Ruifeng, et al.
Publicado: (2014)

A framework for production of systematic review based briefings to support evidence-informed decision-making
por: Chambers, Duncan, et al.
Publicado: (2012)

Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast
por: Staudacher, Jennifer, et al.
Publicado: (2021)

Automated generation of massive image knowledge collections using Microsoft Live Labs Pivot to promote neuroimaging and translational research
por: Viangteeravat, Teeradache, et al.
Publicado: (2011)

Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service
por: Witt, Claudia M, et al.
Publicado: (2015)

Characterization of oligopeptide patterns in large protein sets
por: Bresell, Anders, et al.
Publicado: (2007)

Rapid-cycle systems modeling to support evidence-informed decision-making during system-wide implementation
por: Sheldrick, R. Christopher, et al.
Publicado: (2021)

IMSE: interaction information attention and molecular structure based drug drug interaction extraction
por: Duan, Biao, et al.
Publicado: (2022)

Application of an integrated multi-criteria decision making AHP-TOPSIS methodology for ETL software selection
por: Hanine, Mohamed, et al.
Publicado: (2016)

A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
por: Wehbe, Firas H., et al.
Publicado: (2009)

Danish translation of a physical function item bank from the Patient-Reported Outcome Measurement Information System (PROMIS)
por: Schnohr, Christina W., et al.
Publicado: (2017)

TaxKB: a knowledge base for new taxane-related drug discovery
por: Murugan, Kasi, et al.
Publicado: (2015)

Integration of Visual and Joint Information to Enable Linear Reaching Motions
por: Eberle, Henry, et al.
Publicado: (2017)

Making a decision about trial participation: the feasibility of measuring deliberation during the informed consent process for clinical trials
por: Gillies, Katie, et al.
Publicado: (2014)

DRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models
por: Li, Quanxue, et al.
Publicado: (2019)

Chemical Entity Semantic Specification: Knowledge representation for efficient semantic cheminformatics and facile data integration
por: Chepelev, Leonid L, et al.
Publicado: (2011)

Weighted analysis of general microarray experiments
por: Sjögren, Anders, et al.
Publicado: (2007)

Consolidation of Imaging Modalities Utilizing Digitally Assisted Visualization Systems: The Development of a Surgical Information Handling Cockpit
por: Brooks, Cassandra C, et al.
Publicado: (2020)

Multilevel modeling and value of information in clinical trial decision support
por: Cui, Yuanyuan, et al.
Publicado: (2014)

Using the Causal Inference Framework to Support Individualized Drug Treatment Decisions Based on Observational Healthcare Data
por: Meid, Andreas D, et al.
Publicado: (2020)

Integrating pathway knowledge with deep neural networks to reduce the dimensionality in single-cell RNA-seq data
por: Gundogdu, Pelin, et al.
Publicado: (2022)

BRCA-Pathway: a structural integration and visualization system of TCGA breast cancer data on KEGG pathways
por: Kim, Inyoung, et al.
Publicado: (2018)

Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments
por: Cake, Caroline, et al.
Publicado: (2022)

Improving knowledge translation for increased engagement and impact in healthcare
por: Eljiz, Kathy, et al.
Publicado: (2020)

A nonparametric Bayesian method of translating machine learning scores to probabilities in clinical decision support
por: Connolly, Brian, et al.
Publicado: (2017)

A theory-informed approach to developing visually mediated interventions to change behaviour using an asthma and physical activity intervention exemplar
por: Murray, Jennifer, et al.
Publicado: (2016)

Improving health information systems for decision making across five sub-Saharan African countries: Implementation strategies from the African Health Initiative
por: Mutale, Wilbroad, et al.
Publicado: (2013)

Designing a rapid response program to support evidence-informed decision-making in the Americas region: using the best available evidence and case studies
por: Haby, Michelle M., et al.
Publicado: (2016)

Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper
por: Chen, Chao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rn2mb21ffttuudarmo3oeqleac