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Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer

BACKGROUND: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. METHODS: Twenty-six patients underwent combined treatment for high-risk node-positiv...

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Autores principales: Rasmusson, Elisabeth, Gunnlaugsson, Adalsteinn, Blom, René, Björk-Eriksson, Thomas, Nilsson, Per, Ahlgen, Göran, Jönsson, Charlotta, Johansson, Karin, Kjellén, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842657/
https://www.ncbi.nlm.nih.gov/pubmed/24252686
http://dx.doi.org/10.1186/1748-717X-8-271
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author Rasmusson, Elisabeth
Gunnlaugsson, Adalsteinn
Blom, René
Björk-Eriksson, Thomas
Nilsson, Per
Ahlgen, Göran
Jönsson, Charlotta
Johansson, Karin
Kjellén, Elisabeth
author_facet Rasmusson, Elisabeth
Gunnlaugsson, Adalsteinn
Blom, René
Björk-Eriksson, Thomas
Nilsson, Per
Ahlgen, Göran
Jönsson, Charlotta
Johansson, Karin
Kjellén, Elisabeth
author_sort Rasmusson, Elisabeth
collection PubMed
description BACKGROUND: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. METHODS: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skåne University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2–4.1). RESULTS: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three patients required treatment with compression stockings. CONCLUSION: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection.
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spelling pubmed-38426572013-11-29 Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer Rasmusson, Elisabeth Gunnlaugsson, Adalsteinn Blom, René Björk-Eriksson, Thomas Nilsson, Per Ahlgen, Göran Jönsson, Charlotta Johansson, Karin Kjellén, Elisabeth Radiat Oncol Research BACKGROUND: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer. METHODS: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skåne University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy. The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2x10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2–4.1). RESULTS: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three patients required treatment with compression stockings. CONCLUSION: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection. BioMed Central 2013-11-19 /pmc/articles/PMC3842657/ /pubmed/24252686 http://dx.doi.org/10.1186/1748-717X-8-271 Text en Copyright © 2013 Rasmusson et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rasmusson, Elisabeth
Gunnlaugsson, Adalsteinn
Blom, René
Björk-Eriksson, Thomas
Nilsson, Per
Ahlgen, Göran
Jönsson, Charlotta
Johansson, Karin
Kjellén, Elisabeth
Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title_full Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title_fullStr Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title_full_unstemmed Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title_short Low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
title_sort low rate of lymphedema after extended pelvic lymphadenectomy followed by pelvic irradiation of node-positive prostate cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842657/
https://www.ncbi.nlm.nih.gov/pubmed/24252686
http://dx.doi.org/10.1186/1748-717X-8-271
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