Dual-acting stapled peptides target both HIV-1 entry and assembly

BACKGROUND: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved...

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Detalles Bibliográficos
Autores principales: Zhang, Hongtao, Curreli, Francesca, Waheed, Abdul A, Mercredi, Peter Y, Mehta, Mansi, Bhargava, Pallavi, Scacalossi, Daniel, Tong, Xiaohe, Lee, Shawn, Cooper, Alan, Summers, Michael F, Freed, Eric O, Debnath, Asim K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842668/
https://www.ncbi.nlm.nih.gov/pubmed/24237936
http://dx.doi.org/10.1186/1742-4690-10-136

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