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Japanese studies on neural circuits and behavior of Caenorhabditis elegans

The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the...

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Autores principales: Sasakura, Hiroyuki, Tsukada, Yuki, Takagi, Shin, Mori, Ikue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842693/
https://www.ncbi.nlm.nih.gov/pubmed/24348340
http://dx.doi.org/10.3389/fncir.2013.00187
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author Sasakura, Hiroyuki
Tsukada, Yuki
Takagi, Shin
Mori, Ikue
author_facet Sasakura, Hiroyuki
Tsukada, Yuki
Takagi, Shin
Mori, Ikue
author_sort Sasakura, Hiroyuki
collection PubMed
description The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher animals, including humans. Recent studies that employ modern imaging and manipulation techniques enable researchers to study the dynamic properties of nervous systems with great precision. Behavioral and molecular genetic analyses of this tiny animal have contributed greatly to the advancement of neural circuit research. Here, we will review the recent studies on the neural circuits of C. elegans that have been conducted in Japan. Several laboratories have established unique and clever methods to study the underlying neuronal substrates of behavioral regulation in C. elegans. The technological advances applied to studies of C. elegans have allowed new approaches for the studies of complex neural systems. Through reviewing the studies on the neuronal circuits of C. elegans in Japan, we will analyze and discuss the directions of neural circuit studies.
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spelling pubmed-38426932013-12-13 Japanese studies on neural circuits and behavior of Caenorhabditis elegans Sasakura, Hiroyuki Tsukada, Yuki Takagi, Shin Mori, Ikue Front Neural Circuits Neuroscience The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher animals, including humans. Recent studies that employ modern imaging and manipulation techniques enable researchers to study the dynamic properties of nervous systems with great precision. Behavioral and molecular genetic analyses of this tiny animal have contributed greatly to the advancement of neural circuit research. Here, we will review the recent studies on the neural circuits of C. elegans that have been conducted in Japan. Several laboratories have established unique and clever methods to study the underlying neuronal substrates of behavioral regulation in C. elegans. The technological advances applied to studies of C. elegans have allowed new approaches for the studies of complex neural systems. Through reviewing the studies on the neuronal circuits of C. elegans in Japan, we will analyze and discuss the directions of neural circuit studies. Frontiers Media S.A. 2013-11-28 /pmc/articles/PMC3842693/ /pubmed/24348340 http://dx.doi.org/10.3389/fncir.2013.00187 Text en Copyright © 2013 Sasakura, Tsukada, Takagi and Mori. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sasakura, Hiroyuki
Tsukada, Yuki
Takagi, Shin
Mori, Ikue
Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title_full Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title_fullStr Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title_full_unstemmed Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title_short Japanese studies on neural circuits and behavior of Caenorhabditis elegans
title_sort japanese studies on neural circuits and behavior of caenorhabditis elegans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842693/
https://www.ncbi.nlm.nih.gov/pubmed/24348340
http://dx.doi.org/10.3389/fncir.2013.00187
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