Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured human airway epithelial cells. The role of NA in viral exit is well established: it releases budding virion...

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Detalles Bibliográficos
Autores principales: Cohen, Miriam, Zhang, Xing-Quan, Senaati, Hooman P, Chen, Hui-Wen, Varki, Nissi M, Schooley, Robert T, Gagneux, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842836/
https://www.ncbi.nlm.nih.gov/pubmed/24261589
http://dx.doi.org/10.1186/1743-422X-10-321

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