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Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations

Zoonoses from wildlife threaten global public health. Hendra virus is one of several zoonotic viral diseases that have recently emerged from Pteropus species fruit-bats (flying-foxes). Most hypotheses regarding persistence of Hendra virus within flying-fox populations emphasize horizontal transmissi...

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Autores principales: Wang, Hsiao-Hsuan, Kung, Nina Y., Grant, William E., Scanlan, Joe C., Field, Hume E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842926/
https://www.ncbi.nlm.nih.gov/pubmed/24312221
http://dx.doi.org/10.1371/journal.pone.0080430
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author Wang, Hsiao-Hsuan
Kung, Nina Y.
Grant, William E.
Scanlan, Joe C.
Field, Hume E.
author_facet Wang, Hsiao-Hsuan
Kung, Nina Y.
Grant, William E.
Scanlan, Joe C.
Field, Hume E.
author_sort Wang, Hsiao-Hsuan
collection PubMed
description Zoonoses from wildlife threaten global public health. Hendra virus is one of several zoonotic viral diseases that have recently emerged from Pteropus species fruit-bats (flying-foxes). Most hypotheses regarding persistence of Hendra virus within flying-fox populations emphasize horizontal transmission within local populations (colonies) via urine and other secretions, and transmission among colonies via migration. As an alternative hypothesis, we explore the role of recrudescence in persistence of Hendra virus in flying-fox populations via computer simulation using a model that integrates published information on the ecology of flying-foxes, and the ecology and epidemiology of Hendra virus. Simulated infection patterns agree with infection patterns observed in the field and suggest that Hendra virus could be maintained in an isolated flying-fox population indefinitely via periodic recrudescence in a manner indistinguishable from maintenance via periodic immigration of infected individuals. Further, post-recrudescence pulses of infectious flying-foxes provide a plausible basis for the observed seasonal clustering of equine cases. Correct understanding of the infection dynamics of Hendra virus in flying-foxes is fundamental to effectively managing risk of infection in horses and humans. Given the lack of clear empirical evidence on how the virus is maintained within populations, the role of recrudescence merits increased attention.
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spelling pubmed-38429262013-12-05 Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations Wang, Hsiao-Hsuan Kung, Nina Y. Grant, William E. Scanlan, Joe C. Field, Hume E. PLoS One Research Article Zoonoses from wildlife threaten global public health. Hendra virus is one of several zoonotic viral diseases that have recently emerged from Pteropus species fruit-bats (flying-foxes). Most hypotheses regarding persistence of Hendra virus within flying-fox populations emphasize horizontal transmission within local populations (colonies) via urine and other secretions, and transmission among colonies via migration. As an alternative hypothesis, we explore the role of recrudescence in persistence of Hendra virus in flying-fox populations via computer simulation using a model that integrates published information on the ecology of flying-foxes, and the ecology and epidemiology of Hendra virus. Simulated infection patterns agree with infection patterns observed in the field and suggest that Hendra virus could be maintained in an isolated flying-fox population indefinitely via periodic recrudescence in a manner indistinguishable from maintenance via periodic immigration of infected individuals. Further, post-recrudescence pulses of infectious flying-foxes provide a plausible basis for the observed seasonal clustering of equine cases. Correct understanding of the infection dynamics of Hendra virus in flying-foxes is fundamental to effectively managing risk of infection in horses and humans. Given the lack of clear empirical evidence on how the virus is maintained within populations, the role of recrudescence merits increased attention. Public Library of Science 2013-11-28 /pmc/articles/PMC3842926/ /pubmed/24312221 http://dx.doi.org/10.1371/journal.pone.0080430 Text en © 2013 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Hsiao-Hsuan
Kung, Nina Y.
Grant, William E.
Scanlan, Joe C.
Field, Hume E.
Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title_full Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title_fullStr Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title_full_unstemmed Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title_short Recrudescent Infection Supports Hendra Virus Persistence in Australian Flying-Fox Populations
title_sort recrudescent infection supports hendra virus persistence in australian flying-fox populations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842926/
https://www.ncbi.nlm.nih.gov/pubmed/24312221
http://dx.doi.org/10.1371/journal.pone.0080430
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