A Dexamethasone Prodrug Reduces the Renal Macrophage Response and Provides Enhanced Resolution of Established Murine Lupus Nephritis

We evaluated the ability of a macromolecular prodrug of dexamethasone (P-Dex) to treat lupus nephritis in (NZB × NZW)F1 mice. We also explored the mechanism underlying the anti-inflammatory effects of this prodrug. P-Dex eliminated albuminuria in most (NZB × NZW)F1 mice. Furthermore, P-Dex reduced t...

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Detalles Bibliográficos
Autores principales: Yuan, Fang, Tabor, Dana E., Nelson, Richard K., Yuan, Hongjiang, Zhang, Yijia, Nuxoll, Jenny, Bynoté, Kimberly K., Lele, Subodh M., Wang, Dong, Gould, Karen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842961/
https://www.ncbi.nlm.nih.gov/pubmed/24312306
http://dx.doi.org/10.1371/journal.pone.0081483

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