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Syntaxin 16 is a master recruitment factor for cytokinesis
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842993/ https://www.ncbi.nlm.nih.gov/pubmed/24109596 http://dx.doi.org/10.1091/mbc.E13-06-0302 |
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author | Neto, Hélia Kaupisch, Alexandra Collins, Louise L. Gould, Gwyn W. |
author_facet | Neto, Hélia Kaupisch, Alexandra Collins, Louise L. Gould, Gwyn W. |
author_sort | Neto, Hélia |
collection | PubMed |
description | Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked. |
format | Online Article Text |
id | pubmed-3842993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38429932014-02-16 Syntaxin 16 is a master recruitment factor for cytokinesis Neto, Hélia Kaupisch, Alexandra Collins, Louise L. Gould, Gwyn W. Mol Biol Cell Articles Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome–associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked. The American Society for Cell Biology 2013-12-01 /pmc/articles/PMC3842993/ /pubmed/24109596 http://dx.doi.org/10.1091/mbc.E13-06-0302 Text en © 2013 Neto et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Articles Neto, Hélia Kaupisch, Alexandra Collins, Louise L. Gould, Gwyn W. Syntaxin 16 is a master recruitment factor for cytokinesis |
title | Syntaxin 16 is a master recruitment factor for cytokinesis |
title_full | Syntaxin 16 is a master recruitment factor for cytokinesis |
title_fullStr | Syntaxin 16 is a master recruitment factor for cytokinesis |
title_full_unstemmed | Syntaxin 16 is a master recruitment factor for cytokinesis |
title_short | Syntaxin 16 is a master recruitment factor for cytokinesis |
title_sort | syntaxin 16 is a master recruitment factor for cytokinesis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842993/ https://www.ncbi.nlm.nih.gov/pubmed/24109596 http://dx.doi.org/10.1091/mbc.E13-06-0302 |
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