WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)

PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) is a protein-serine/threonine phosphatase and a negative regulator of the PI3-kinase/Akt pathway. Although its function as a suppressor of tumor cell growth has been established, the mechanism of its regulation is not completely understood...

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Detalles Bibliográficos
Autores principales: Gangula, Narmadha Reddy, Maddika, Subbareddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843068/
https://www.ncbi.nlm.nih.gov/pubmed/24145035
http://dx.doi.org/10.1074/jbc.M113.503383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843068/
https://www.ncbi.nlm.nih.gov/pubmed/24145035
http://dx.doi.org/10.1074/jbc.M113.503383

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