Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity

Ectopic lymphoid tissue, also known as tertiary lymphoid organs (TLO) develop adaptively within sites of chronic tissue inflammation, thereby allowing the host to efficiently crossprime specific immune effector cells within sites of disease. Recent evidence suggests that the presence of TLO in the t...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Fabian, Kellsye L., Taylor, Jennifer L., Storkus, Walter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843121/
https://www.ncbi.nlm.nih.gov/pubmed/24348473
http://dx.doi.org/10.3389/fimmu.2013.00388
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author Chen, Lu
Fabian, Kellsye L.
Taylor, Jennifer L.
Storkus, Walter J.
author_facet Chen, Lu
Fabian, Kellsye L.
Taylor, Jennifer L.
Storkus, Walter J.
author_sort Chen, Lu
collection PubMed
description Ectopic lymphoid tissue, also known as tertiary lymphoid organs (TLO) develop adaptively within sites of chronic tissue inflammation, thereby allowing the host to efficiently crossprime specific immune effector cells within sites of disease. Recent evidence suggests that the presence of TLO in the tumor microenvironment (TME) predicts better overall survival. We will discuss the relevance of extranodal T cell priming within the TME as a means to effectively promote anti-tumor immunity and the strategic use of dendritic cell (DC)-based therapies to reinforce this clinically preferred process in the cancer-bearing host.
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spelling pubmed-38431212013-12-13 Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity Chen, Lu Fabian, Kellsye L. Taylor, Jennifer L. Storkus, Walter J. Front Immunol Immunology Ectopic lymphoid tissue, also known as tertiary lymphoid organs (TLO) develop adaptively within sites of chronic tissue inflammation, thereby allowing the host to efficiently crossprime specific immune effector cells within sites of disease. Recent evidence suggests that the presence of TLO in the tumor microenvironment (TME) predicts better overall survival. We will discuss the relevance of extranodal T cell priming within the TME as a means to effectively promote anti-tumor immunity and the strategic use of dendritic cell (DC)-based therapies to reinforce this clinically preferred process in the cancer-bearing host. Frontiers Media S.A. 2013-11-29 /pmc/articles/PMC3843121/ /pubmed/24348473 http://dx.doi.org/10.3389/fimmu.2013.00388 Text en Copyright © 2013 Chen, Fabian, Taylor and Storkus. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Lu
Fabian, Kellsye L.
Taylor, Jennifer L.
Storkus, Walter J.
Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title_full Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title_fullStr Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title_full_unstemmed Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title_short Therapeutic Use of Dendritic Cells to Promote the Extranodal Priming of Anti-Tumor Immunity
title_sort therapeutic use of dendritic cells to promote the extranodal priming of anti-tumor immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843121/
https://www.ncbi.nlm.nih.gov/pubmed/24348473
http://dx.doi.org/10.3389/fimmu.2013.00388
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