MUTATIONS IN THE GABRB1 GENE PROMOTE ALCOHOL CONSUMPTION THROUGH INCREASED TONIC INHIBITION

Alcohol-dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acid(A) receptor (GABA(A)R) β1 subunit gene (Gabrb1). Using N-ethyl-N-nitrosourea mutagenesis on an a...

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Detalles Bibliográficos
Autores principales: Anstee, Quentin M., Knapp, Susanne, Maguire, Edward P., Hosie, Alastair M., Thomas, Philip, Mortensen, Martin, Bhome, Rohan, Martinez, Alonso, Walker, Sophie E., Dixon, Claire I., Ruparelia, Kush, Montagnese, Sara, Kuo, Yu-Ting, Herlihy, Amy, Bell, Jimmy D, Robinson, Iain, Guerrini, Irene, McQuillin, Andrew, Fisher, Elizabeth M.C., Ungless, Mark A., Gurling, Hugh M.D., Morgan, Marsha Y., Brown, Steve D.M., Stephens, David N., Belelli, Delia, Lambert, Jeremy J., Smart, Trevor G., Thomas, Howard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843143/
https://www.ncbi.nlm.nih.gov/pubmed/24281383
http://dx.doi.org/10.1038/ncomms3816

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