Cargando…

Gout with auricular tophi following anti-tuberculosis treatment: a case report

BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Hsin-Jen, Wang, Pa-Chun, Hsu, Ying-Chieh, Huang, Shih-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843551/
https://www.ncbi.nlm.nih.gov/pubmed/24256949
http://dx.doi.org/10.1186/1756-0500-6-480
_version_ 1782293063726530560
author Chang, Hsin-Jen
Wang, Pa-Chun
Hsu, Ying-Chieh
Huang, Shih-Hung
author_facet Chang, Hsin-Jen
Wang, Pa-Chun
Hsu, Ying-Chieh
Huang, Shih-Hung
author_sort Chang, Hsin-Jen
collection PubMed
description BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year-old man who had multiple painless nodules over bilateral helix. An excisional biopsy was performed. Hematoxylin-eosin staining of biopsy specimens revealed a proteinaceous matrix that surrounded dissolved crystals, consistent with gout tophi. Bilateral auricular tophi are not common and may resemble a number of other diseases including squamous cell carcinomas, Kaposi’s sarcoma, epidermal and dermoid cysts, rheumatoid nodules. Biopsy should be performed to rule out malignancy. CONCLUSIONS: Tophi of the auricle are usually asymptomatic but can become inflamed and occasionally ulcerate through the overlying skin. Chronic tophaceous gout is treated with dietary control and medication. Surgical excision is performed under local anesthetic if symptoms progression or cosmetically deformity is concerned.
format Online
Article
Text
id pubmed-3843551
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-38435512013-11-30 Gout with auricular tophi following anti-tuberculosis treatment: a case report Chang, Hsin-Jen Wang, Pa-Chun Hsu, Ying-Chieh Huang, Shih-Hung BMC Res Notes Case Report BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year-old man who had multiple painless nodules over bilateral helix. An excisional biopsy was performed. Hematoxylin-eosin staining of biopsy specimens revealed a proteinaceous matrix that surrounded dissolved crystals, consistent with gout tophi. Bilateral auricular tophi are not common and may resemble a number of other diseases including squamous cell carcinomas, Kaposi’s sarcoma, epidermal and dermoid cysts, rheumatoid nodules. Biopsy should be performed to rule out malignancy. CONCLUSIONS: Tophi of the auricle are usually asymptomatic but can become inflamed and occasionally ulcerate through the overlying skin. Chronic tophaceous gout is treated with dietary control and medication. Surgical excision is performed under local anesthetic if symptoms progression or cosmetically deformity is concerned. BioMed Central 2013-11-21 /pmc/articles/PMC3843551/ /pubmed/24256949 http://dx.doi.org/10.1186/1756-0500-6-480 Text en Copyright © 2013 Chang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, Hsin-Jen
Wang, Pa-Chun
Hsu, Ying-Chieh
Huang, Shih-Hung
Gout with auricular tophi following anti-tuberculosis treatment: a case report
title Gout with auricular tophi following anti-tuberculosis treatment: a case report
title_full Gout with auricular tophi following anti-tuberculosis treatment: a case report
title_fullStr Gout with auricular tophi following anti-tuberculosis treatment: a case report
title_full_unstemmed Gout with auricular tophi following anti-tuberculosis treatment: a case report
title_short Gout with auricular tophi following anti-tuberculosis treatment: a case report
title_sort gout with auricular tophi following anti-tuberculosis treatment: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843551/
https://www.ncbi.nlm.nih.gov/pubmed/24256949
http://dx.doi.org/10.1186/1756-0500-6-480
work_keys_str_mv AT changhsinjen goutwithauriculartophifollowingantituberculosistreatmentacasereport
AT wangpachun goutwithauriculartophifollowingantituberculosistreatmentacasereport
AT hsuyingchieh goutwithauriculartophifollowingantituberculosistreatmentacasereport
AT huangshihhung goutwithauriculartophifollowingantituberculosistreatmentacasereport