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Gout with auricular tophi following anti-tuberculosis treatment: a case report
BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843551/ https://www.ncbi.nlm.nih.gov/pubmed/24256949 http://dx.doi.org/10.1186/1756-0500-6-480 |
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author | Chang, Hsin-Jen Wang, Pa-Chun Hsu, Ying-Chieh Huang, Shih-Hung |
author_facet | Chang, Hsin-Jen Wang, Pa-Chun Hsu, Ying-Chieh Huang, Shih-Hung |
author_sort | Chang, Hsin-Jen |
collection | PubMed |
description | BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year-old man who had multiple painless nodules over bilateral helix. An excisional biopsy was performed. Hematoxylin-eosin staining of biopsy specimens revealed a proteinaceous matrix that surrounded dissolved crystals, consistent with gout tophi. Bilateral auricular tophi are not common and may resemble a number of other diseases including squamous cell carcinomas, Kaposi’s sarcoma, epidermal and dermoid cysts, rheumatoid nodules. Biopsy should be performed to rule out malignancy. CONCLUSIONS: Tophi of the auricle are usually asymptomatic but can become inflamed and occasionally ulcerate through the overlying skin. Chronic tophaceous gout is treated with dietary control and medication. Surgical excision is performed under local anesthetic if symptoms progression or cosmetically deformity is concerned. |
format | Online Article Text |
id | pubmed-3843551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38435512013-11-30 Gout with auricular tophi following anti-tuberculosis treatment: a case report Chang, Hsin-Jen Wang, Pa-Chun Hsu, Ying-Chieh Huang, Shih-Hung BMC Res Notes Case Report BACKGROUND: Auricular tophi are firm deposits of monosodium urate in crystal form, which may slowly develop in subcutaneous tissue of the ear. Ear is not usual locations for gout tophi, but when this growth does occur, helix and the antihelix are common sites. CASE PRESENTATION: We present a 64-year-old man who had multiple painless nodules over bilateral helix. An excisional biopsy was performed. Hematoxylin-eosin staining of biopsy specimens revealed a proteinaceous matrix that surrounded dissolved crystals, consistent with gout tophi. Bilateral auricular tophi are not common and may resemble a number of other diseases including squamous cell carcinomas, Kaposi’s sarcoma, epidermal and dermoid cysts, rheumatoid nodules. Biopsy should be performed to rule out malignancy. CONCLUSIONS: Tophi of the auricle are usually asymptomatic but can become inflamed and occasionally ulcerate through the overlying skin. Chronic tophaceous gout is treated with dietary control and medication. Surgical excision is performed under local anesthetic if symptoms progression or cosmetically deformity is concerned. BioMed Central 2013-11-21 /pmc/articles/PMC3843551/ /pubmed/24256949 http://dx.doi.org/10.1186/1756-0500-6-480 Text en Copyright © 2013 Chang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Chang, Hsin-Jen Wang, Pa-Chun Hsu, Ying-Chieh Huang, Shih-Hung Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title | Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title_full | Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title_fullStr | Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title_full_unstemmed | Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title_short | Gout with auricular tophi following anti-tuberculosis treatment: a case report |
title_sort | gout with auricular tophi following anti-tuberculosis treatment: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843551/ https://www.ncbi.nlm.nih.gov/pubmed/24256949 http://dx.doi.org/10.1186/1756-0500-6-480 |
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