Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii

BACKGROUND: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently...

Descripción completa

Detalles Bibliográficos
Autores principales: Khatri, Indu, Akhtar, Akil, Kaur, Kamaldeep, Tomar, Rajul, Prasad, Gandham Satyanarayana, Ramya, Thirumalai Nallan Chakravarthy, Subramanian, Srikrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843575/
https://www.ncbi.nlm.nih.gov/pubmed/24148866
http://dx.doi.org/10.1186/1757-4749-5-30
Descripción
Sumario:BACKGROUND: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain. RESULTS: We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes. CONCLUSIONS: Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.

Ejemplares similares