Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii

BACKGROUND: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently...

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Autores principales: Khatri, Indu, Akhtar, Akil, Kaur, Kamaldeep, Tomar, Rajul, Prasad, Gandham Satyanarayana, Ramya, Thirumalai Nallan Chakravarthy, Subramanian, Srikrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843575/
https://www.ncbi.nlm.nih.gov/pubmed/24148866
http://dx.doi.org/10.1186/1757-4749-5-30
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author Khatri, Indu
Akhtar, Akil
Kaur, Kamaldeep
Tomar, Rajul
Prasad, Gandham Satyanarayana
Ramya, Thirumalai Nallan Chakravarthy
Subramanian, Srikrishna
author_facet Khatri, Indu
Akhtar, Akil
Kaur, Kamaldeep
Tomar, Rajul
Prasad, Gandham Satyanarayana
Ramya, Thirumalai Nallan Chakravarthy
Subramanian, Srikrishna
author_sort Khatri, Indu
collection PubMed
description BACKGROUND: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain. RESULTS: We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes. CONCLUSIONS: Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.
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spelling pubmed-38435752013-11-30 Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii Khatri, Indu Akhtar, Akil Kaur, Kamaldeep Tomar, Rajul Prasad, Gandham Satyanarayana Ramya, Thirumalai Nallan Chakravarthy Subramanian, Srikrishna Gut Pathog Research BACKGROUND: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain. RESULTS: We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes. CONCLUSIONS: Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties. BioMed Central 2013-10-22 /pmc/articles/PMC3843575/ /pubmed/24148866 http://dx.doi.org/10.1186/1757-4749-5-30 Text en Copyright © 2013 Khatri et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Khatri, Indu
Akhtar, Akil
Kaur, Kamaldeep
Tomar, Rajul
Prasad, Gandham Satyanarayana
Ramya, Thirumalai Nallan Chakravarthy
Subramanian, Srikrishna
Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title_full Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title_fullStr Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title_full_unstemmed Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title_short Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
title_sort gleaning evolutionary insights from the genome sequence of a probiotic yeast saccharomyces boulardii
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843575/
https://www.ncbi.nlm.nih.gov/pubmed/24148866
http://dx.doi.org/10.1186/1757-4749-5-30
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