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Both Positive and Negative Selection Pressures Contribute to the Polymorphism Pattern of the Duplicated Human CYP21A2 Gene

The human steroid 21-hydroxylase gene (CYP21A2) participates in cortisol and aldosterone biosynthesis, and resides together with its paralogous (duplicated) pseudogene in a multiallelic copy number variation (CNV), called RCCX CNV. Concerted evolution caused by non-allelic gene conversion has been d...

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Detalles Bibliográficos
Autores principales:	Szabó, Julianna Anna, Szilágyi, Ágnes, Doleschall, Zoltán, Patócs, Attila, Farkas, Henriette, Prohászka, Zoltán, Rácz, Kárioly, Füst, George, Doleschall, Márton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843699/ https://www.ncbi.nlm.nih.gov/pubmed/24312389 http://dx.doi.org/10.1371/journal.pone.0081977

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