Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in...

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Autores principales: Li, Yihua, Yang, Wenge, Zhang, Tuan, Wang, Chaoyuan, Wang, Kai, Hu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843816/
https://www.ncbi.nlm.nih.gov/pubmed/24319302
http://dx.doi.org/10.1007/s10953-013-0110-y
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author Li, Yihua
Yang, Wenge
Zhang, Tuan
Wang, Chaoyuan
Wang, Kai
Hu, Yonghong
author_facet Li, Yihua
Yang, Wenge
Zhang, Tuan
Wang, Chaoyuan
Wang, Kai
Hu, Yonghong
author_sort Li, Yihua
collection PubMed
description Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation.
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spelling pubmed-38438162013-12-04 Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K Li, Yihua Yang, Wenge Zhang, Tuan Wang, Chaoyuan Wang, Kai Hu, Yonghong J Solution Chem Article Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation. Springer US 2013-11-12 2013 /pmc/articles/PMC3843816/ /pubmed/24319302 http://dx.doi.org/10.1007/s10953-013-0110-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Li, Yihua
Yang, Wenge
Zhang, Tuan
Wang, Chaoyuan
Wang, Kai
Hu, Yonghong
Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title_full Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title_fullStr Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title_full_unstemmed Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title_short Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K
title_sort solubility of omeprazole sulfide in different solvents at the range of 280.35–319.65 k
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843816/
https://www.ncbi.nlm.nih.gov/pubmed/24319302
http://dx.doi.org/10.1007/s10953-013-0110-y
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