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The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos
Lineage specification in the preimplantation mouse embryo is a regulative process. Thus, it has been difficult to ascertain whether segregation of the inner-cell-mass (ICM) into precursors of the pluripotent epiblast (EPI) and the differentiating primitive endoderm (PE) is random or influenced by de...
Autores principales: | Morris, Samantha A., Graham, Sarah J. L., Jedrusik, Agnieszka, Zernicka-Goetz, Magdalena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843820/ https://www.ncbi.nlm.nih.gov/pubmed/24258274 http://dx.doi.org/10.1098/rsob.130104 |
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