Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease

Idiopathic orbital inflammatory disease (IOID) is an idiopathic inflammatory process within the orbit that can result in permanent visual impairment. Although high-dose oral corticosteroids are currently the mainstay of therapy, their long-term usage can cause significant toxicity. We present a case...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Emily H., Karydis, Andreas, Gemenetzi, Maria, Taylor, Simon R.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: November, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843906/
https://www.ncbi.nlm.nih.gov/pubmed/24348405
http://dx.doi.org/10.1159/000356523
_version_ 1782293111115874304
author Shao, Emily H.
Karydis, Andreas
Gemenetzi, Maria
Taylor, Simon R.J.
author_facet Shao, Emily H.
Karydis, Andreas
Gemenetzi, Maria
Taylor, Simon R.J.
author_sort Shao, Emily H.
collection PubMed
description Idiopathic orbital inflammatory disease (IOID) is an idiopathic inflammatory process within the orbit that can result in permanent visual impairment. Although high-dose oral corticosteroids are currently the mainstay of therapy, their long-term usage can cause significant toxicity. We present a case of IOID that was successfully treated with the anti-CD20 monoclonal antibody rituximab following failed steroid sparing with conventional second-line immunosuppressive agents.
format Online
Article
Text
id pubmed-3843906
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-38439062013-12-12 Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease Shao, Emily H. Karydis, Andreas Gemenetzi, Maria Taylor, Simon R.J. Case Rep Ophthalmol Published online: November, 2013 Idiopathic orbital inflammatory disease (IOID) is an idiopathic inflammatory process within the orbit that can result in permanent visual impairment. Although high-dose oral corticosteroids are currently the mainstay of therapy, their long-term usage can cause significant toxicity. We present a case of IOID that was successfully treated with the anti-CD20 monoclonal antibody rituximab following failed steroid sparing with conventional second-line immunosuppressive agents. S. Karger AG 2013-11-01 /pmc/articles/PMC3843906/ /pubmed/24348405 http://dx.doi.org/10.1159/000356523 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: November, 2013
Shao, Emily H.
Karydis, Andreas
Gemenetzi, Maria
Taylor, Simon R.J.
Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title_full Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title_fullStr Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title_full_unstemmed Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title_short Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease
title_sort successful corticosteroid-sparing effect of rituximab in the treatment of refractory idiopathic orbital inflammatory disease
topic Published online: November, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843906/
https://www.ncbi.nlm.nih.gov/pubmed/24348405
http://dx.doi.org/10.1159/000356523
work_keys_str_mv AT shaoemilyh successfulcorticosteroidsparingeffectofrituximabinthetreatmentofrefractoryidiopathicorbitalinflammatorydisease
AT karydisandreas successfulcorticosteroidsparingeffectofrituximabinthetreatmentofrefractoryidiopathicorbitalinflammatorydisease
AT gemenetzimaria successfulcorticosteroidsparingeffectofrituximabinthetreatmentofrefractoryidiopathicorbitalinflammatorydisease
AT taylorsimonrj successfulcorticosteroidsparingeffectofrituximabinthetreatmentofrefractoryidiopathicorbitalinflammatorydisease

Ejemplares similares