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The risk of atherosclerosis in patients with chronic kidney disease

BACKGROUND: Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising, especially in industrialized countries. A major complication of CKD is cardiovascular disease. Accelerated atherosclerosis has been observed in early st...

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Autores principales: Olechnowicz-Tietz, Sylwia, Gluba, Anna, Paradowska, Anna, Banach, Maciej, Rysz, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844144/
https://www.ncbi.nlm.nih.gov/pubmed/23483304
http://dx.doi.org/10.1007/s11255-013-0407-1
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author Olechnowicz-Tietz, Sylwia
Gluba, Anna
Paradowska, Anna
Banach, Maciej
Rysz, Jacek
author_facet Olechnowicz-Tietz, Sylwia
Gluba, Anna
Paradowska, Anna
Banach, Maciej
Rysz, Jacek
author_sort Olechnowicz-Tietz, Sylwia
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising, especially in industrialized countries. A major complication of CKD is cardiovascular disease. Accelerated atherosclerosis has been observed in early stages of renal dysfunction. The purpose of this study was to examine the relationship between the degree of renal insufficiency and both the prevalence and intensity of coronary artery disease (assessed on the basis of number of vessels with stenosis). METHODS: 446 individuals with both serum creatinine >120 μmol/l (men) or >96 μmol/l (women) and acute coronary syndrome were included in the study. All patients included in this analysis underwent urgent coronarography. Data concerning glomerular filtration rate (GFR), number of vessels with stenosis, hypertension, lipid disorders, creatinine concentration, C-reactive protein, glucose and lipid profile were analyzed. RESULTS: This study confirmed that moderate to severe renal impairment is associated with accelerated atherosclerosis. Moreover, patients with GFR values below 60 ml/min/1.73 m(2) are predisposed to accelerated, multivessel cardiovascular disease. CONCLUSIONS: GFR seems to be an independent risk factor for multivessel cardiovascular disease. Due to the fact that patients with renal dysfunction are at high risk of cardiovascular events, they should obtain optimal treatment resulting not only in kidney protection but also in the elimination of cardiovascular risk factors.
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spelling pubmed-38441442013-12-04 The risk of atherosclerosis in patients with chronic kidney disease Olechnowicz-Tietz, Sylwia Gluba, Anna Paradowska, Anna Banach, Maciej Rysz, Jacek Int Urol Nephrol Nephrology - Original Paper BACKGROUND: Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising, especially in industrialized countries. A major complication of CKD is cardiovascular disease. Accelerated atherosclerosis has been observed in early stages of renal dysfunction. The purpose of this study was to examine the relationship between the degree of renal insufficiency and both the prevalence and intensity of coronary artery disease (assessed on the basis of number of vessels with stenosis). METHODS: 446 individuals with both serum creatinine >120 μmol/l (men) or >96 μmol/l (women) and acute coronary syndrome were included in the study. All patients included in this analysis underwent urgent coronarography. Data concerning glomerular filtration rate (GFR), number of vessels with stenosis, hypertension, lipid disorders, creatinine concentration, C-reactive protein, glucose and lipid profile were analyzed. RESULTS: This study confirmed that moderate to severe renal impairment is associated with accelerated atherosclerosis. Moreover, patients with GFR values below 60 ml/min/1.73 m(2) are predisposed to accelerated, multivessel cardiovascular disease. CONCLUSIONS: GFR seems to be an independent risk factor for multivessel cardiovascular disease. Due to the fact that patients with renal dysfunction are at high risk of cardiovascular events, they should obtain optimal treatment resulting not only in kidney protection but also in the elimination of cardiovascular risk factors. Springer Netherlands 2013-03-13 2013 /pmc/articles/PMC3844144/ /pubmed/23483304 http://dx.doi.org/10.1007/s11255-013-0407-1 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Nephrology - Original Paper
Olechnowicz-Tietz, Sylwia
Gluba, Anna
Paradowska, Anna
Banach, Maciej
Rysz, Jacek
The risk of atherosclerosis in patients with chronic kidney disease
title The risk of atherosclerosis in patients with chronic kidney disease
title_full The risk of atherosclerosis in patients with chronic kidney disease
title_fullStr The risk of atherosclerosis in patients with chronic kidney disease
title_full_unstemmed The risk of atherosclerosis in patients with chronic kidney disease
title_short The risk of atherosclerosis in patients with chronic kidney disease
title_sort risk of atherosclerosis in patients with chronic kidney disease
topic Nephrology - Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844144/
https://www.ncbi.nlm.nih.gov/pubmed/23483304
http://dx.doi.org/10.1007/s11255-013-0407-1
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