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Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults

AIMS: Aircraft noise disturbs sleep, and long-term exposure has been shown to be associated with increases in the prevalence of hypertension and an overall increased risk for myocardial infarction. The exact mechanisms responsible for these cardiovascular effects remain unclear. METHODS AND RESULTS:...

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Autores principales: Schmidt, Frank P., Basner, Mathias, Kröger, Gunnar, Weck, Stefanie, Schnorbus, Boris, Muttray, Axel, Sariyar, Murat, Binder, Harald, Gori, Tommaso, Warnholtz, Ascan, Münzel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844151/
https://www.ncbi.nlm.nih.gov/pubmed/23821397
http://dx.doi.org/10.1093/eurheartj/eht269
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author Schmidt, Frank P.
Basner, Mathias
Kröger, Gunnar
Weck, Stefanie
Schnorbus, Boris
Muttray, Axel
Sariyar, Murat
Binder, Harald
Gori, Tommaso
Warnholtz, Ascan
Münzel, Thomas
author_facet Schmidt, Frank P.
Basner, Mathias
Kröger, Gunnar
Weck, Stefanie
Schnorbus, Boris
Muttray, Axel
Sariyar, Murat
Binder, Harald
Gori, Tommaso
Warnholtz, Ascan
Münzel, Thomas
author_sort Schmidt, Frank P.
collection PubMed
description AIMS: Aircraft noise disturbs sleep, and long-term exposure has been shown to be associated with increases in the prevalence of hypertension and an overall increased risk for myocardial infarction. The exact mechanisms responsible for these cardiovascular effects remain unclear. METHODS AND RESULTS: We performed a blinded field study in 75 healthy volunteers (mean age 26 years), who were exposed at home, in random order, to one control pattern (no noise) and two different noise scenarios [30 or 60 aircraft noise events per night with an average maximum sound pressure level (SPL) of 60 dB(A)] for one night each. We performed polygraphy during each study night. Noise caused a worsening in sleep quality (P < 0.0001). Noise60, corresponding to equivalent continuous SPLs of 46.3 dB (Leq) and representing environmental noise levels associated with increased cardiovascular events, caused a blunting in FMD (P = 0.016). As well, although a direct comparison among the FMD values in the noise groups (control: 10.4 ± 3.8%; Noise30: 9.7 ± 4.1%; Noise60: 9.5 ± 4.3%, P = 0.052) did not reach significance, a monotone dose-dependent effect of noise level on FMD was shown (P = 0.020). Finally, there was a priming effect of noise, i.e. the blunting in FMD was particularly evident when subjects were exposed first to 30 and then to 60 noise events (P = 0.006). Noise-induced endothelial dysfunction (ED) was reversed by the administration of Vitamin C (P = 0.0171). Morning adrenaline concentration increased from 28.3 ± 10.9 to 33.2 ± 16.6 and 34.1 ± 19.3 ng/L (P = 0.0099). Pulse transit time, reflecting arterial stiffness, was also shorter after exposure to noise (P = 0.003). CONCLUSION: In healthy adults, acute nighttime aircraft noise exposure dose-dependently impairs endothelial function and stimulates adrenaline release. Noise-induced ED may be in part due to increased production in reactive oxygen species and may thus be one mechanism contributing to the observed association of chronic noise exposure with cardiovascular disease.
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spelling pubmed-38441512013-12-02 Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults Schmidt, Frank P. Basner, Mathias Kröger, Gunnar Weck, Stefanie Schnorbus, Boris Muttray, Axel Sariyar, Murat Binder, Harald Gori, Tommaso Warnholtz, Ascan Münzel, Thomas Eur Heart J Clinical Research AIMS: Aircraft noise disturbs sleep, and long-term exposure has been shown to be associated with increases in the prevalence of hypertension and an overall increased risk for myocardial infarction. The exact mechanisms responsible for these cardiovascular effects remain unclear. METHODS AND RESULTS: We performed a blinded field study in 75 healthy volunteers (mean age 26 years), who were exposed at home, in random order, to one control pattern (no noise) and two different noise scenarios [30 or 60 aircraft noise events per night with an average maximum sound pressure level (SPL) of 60 dB(A)] for one night each. We performed polygraphy during each study night. Noise caused a worsening in sleep quality (P < 0.0001). Noise60, corresponding to equivalent continuous SPLs of 46.3 dB (Leq) and representing environmental noise levels associated with increased cardiovascular events, caused a blunting in FMD (P = 0.016). As well, although a direct comparison among the FMD values in the noise groups (control: 10.4 ± 3.8%; Noise30: 9.7 ± 4.1%; Noise60: 9.5 ± 4.3%, P = 0.052) did not reach significance, a monotone dose-dependent effect of noise level on FMD was shown (P = 0.020). Finally, there was a priming effect of noise, i.e. the blunting in FMD was particularly evident when subjects were exposed first to 30 and then to 60 noise events (P = 0.006). Noise-induced endothelial dysfunction (ED) was reversed by the administration of Vitamin C (P = 0.0171). Morning adrenaline concentration increased from 28.3 ± 10.9 to 33.2 ± 16.6 and 34.1 ± 19.3 ng/L (P = 0.0099). Pulse transit time, reflecting arterial stiffness, was also shorter after exposure to noise (P = 0.003). CONCLUSION: In healthy adults, acute nighttime aircraft noise exposure dose-dependently impairs endothelial function and stimulates adrenaline release. Noise-induced ED may be in part due to increased production in reactive oxygen species and may thus be one mechanism contributing to the observed association of chronic noise exposure with cardiovascular disease. Oxford University Press 2013-12-01 2013-07-02 /pmc/articles/PMC3844151/ /pubmed/23821397 http://dx.doi.org/10.1093/eurheartj/eht269 Text en © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Research
Schmidt, Frank P.
Basner, Mathias
Kröger, Gunnar
Weck, Stefanie
Schnorbus, Boris
Muttray, Axel
Sariyar, Murat
Binder, Harald
Gori, Tommaso
Warnholtz, Ascan
Münzel, Thomas
Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title_full Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title_fullStr Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title_full_unstemmed Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title_short Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
title_sort effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844151/
https://www.ncbi.nlm.nih.gov/pubmed/23821397
http://dx.doi.org/10.1093/eurheartj/eht269
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