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Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by an imbalanced redox state and increased apoptosis. Tropical infections, particularly malaria, may confer protection against SLE. Oxidative stress is a hallmark of SLE. We have measured changes in the levels of nit...

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Autores principales: Al-Quraishy, Saleh, Abdel-Maksoud, Mostafa A., El-Amir, Azza, Abdel-Ghaffar, Fathy A., Badr, Gamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844167/
https://www.ncbi.nlm.nih.gov/pubmed/24319531
http://dx.doi.org/10.1155/2013/156562
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author Al-Quraishy, Saleh
Abdel-Maksoud, Mostafa A.
El-Amir, Azza
Abdel-Ghaffar, Fathy A.
Badr, Gamal
author_facet Al-Quraishy, Saleh
Abdel-Maksoud, Mostafa A.
El-Amir, Azza
Abdel-Ghaffar, Fathy A.
Badr, Gamal
author_sort Al-Quraishy, Saleh
collection PubMed
description Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by an imbalanced redox state and increased apoptosis. Tropical infections, particularly malaria, may confer protection against SLE. Oxidative stress is a hallmark of SLE. We have measured changes in the levels of nitric oxide (NO), hydrogen peroxide (H(2)O(2)), malondialdehyde (MDA), and reduced glutathione (GSH) in both kidney and liver tissues of female BWF1 lupus mice, an experimental model of SLE, after infection with either live or gamma-irradiated malaria. We observed a decrease in NO, H(2)O(2), and MDA levels in kidney tissues after infection of lupus mice with live malaria. Similarly, the levels of NO and H(2)O(2) were significantly decreased in the liver tissues of lupus mice after infection with live malaria. Conversely, GSH levels were obviously increased in both kidney and liver tissues after infection of lupus mice with either live or gamma-irradiated malaria. Liver and kidney functions were significantly altered after infection of lupus mice with live malaria. We further investigated the ultrastructural changes and detected the number of apoptotic cells in kidney and liver tissues in situ by electron microscopy and TUNEL assays. Our data reveal that infection of lupus mice with malaria confers protection against lupus nephritis.
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spelling pubmed-38441672013-12-08 Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis Al-Quraishy, Saleh Abdel-Maksoud, Mostafa A. El-Amir, Azza Abdel-Ghaffar, Fathy A. Badr, Gamal Oxid Med Cell Longev Research Article Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by an imbalanced redox state and increased apoptosis. Tropical infections, particularly malaria, may confer protection against SLE. Oxidative stress is a hallmark of SLE. We have measured changes in the levels of nitric oxide (NO), hydrogen peroxide (H(2)O(2)), malondialdehyde (MDA), and reduced glutathione (GSH) in both kidney and liver tissues of female BWF1 lupus mice, an experimental model of SLE, after infection with either live or gamma-irradiated malaria. We observed a decrease in NO, H(2)O(2), and MDA levels in kidney tissues after infection of lupus mice with live malaria. Similarly, the levels of NO and H(2)O(2) were significantly decreased in the liver tissues of lupus mice after infection with live malaria. Conversely, GSH levels were obviously increased in both kidney and liver tissues after infection of lupus mice with either live or gamma-irradiated malaria. Liver and kidney functions were significantly altered after infection of lupus mice with live malaria. We further investigated the ultrastructural changes and detected the number of apoptotic cells in kidney and liver tissues in situ by electron microscopy and TUNEL assays. Our data reveal that infection of lupus mice with malaria confers protection against lupus nephritis. Hindawi Publishing Corporation 2013 2013-11-10 /pmc/articles/PMC3844167/ /pubmed/24319531 http://dx.doi.org/10.1155/2013/156562 Text en Copyright © 2013 Saleh Al-Quraishy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Quraishy, Saleh
Abdel-Maksoud, Mostafa A.
El-Amir, Azza
Abdel-Ghaffar, Fathy A.
Badr, Gamal
Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title_full Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title_fullStr Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title_full_unstemmed Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title_short Malarial Infection of Female BWF1 Lupus Mice Alters the Redox State in Kidney and Liver Tissues and Confers Protection against Lupus Nephritis
title_sort malarial infection of female bwf1 lupus mice alters the redox state in kidney and liver tissues and confers protection against lupus nephritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844167/
https://www.ncbi.nlm.nih.gov/pubmed/24319531
http://dx.doi.org/10.1155/2013/156562
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