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Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients

Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (st...

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Detalles Bibliográficos
Autores principales: Kawamoto, Ryuichi, Katoh, Tateaki, Kusunoki, Tomo, Ohtsuka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844178/
https://www.ncbi.nlm.nih.gov/pubmed/24319597
http://dx.doi.org/10.1155/2013/979481
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author Kawamoto, Ryuichi
Katoh, Tateaki
Kusunoki, Tomo
Ohtsuka, Nobuyuki
author_facet Kawamoto, Ryuichi
Katoh, Tateaki
Kusunoki, Tomo
Ohtsuka, Nobuyuki
author_sort Kawamoto, Ryuichi
collection PubMed
description Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on the presence of CVD. We cross-sectionally assessed the ability of carotid IMT to identify CVD corresponding to treatment that was examined by receiver-operating characteristic (ROC) curve analyses. Among the 271 diabetic patients, 199 non-CVD and 72 CVD patients were examined. Multiple linear regression analysis using the presence of CVD as an objective variable showed that carotid IMT (β = 0.259, P < 0.001) as well as other confounding factors was a significant independent contributing factor. The ROC curve analysis showed that the best marker of CVD was carotid IMT, with an area under the ROC curve of 0.718 (95% confidence interval (CI), 0.650–0.785). The greatest sensitivity and specificity were obtained when the cut-off value of mean carotid IMT was set at 0.95 mm (sensitivity = 0.71, specificity = 0.60, and accuracy = 0.627). Our study suggests that carotid IMT may be useful for screening diabetic patients with CVD.
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spelling pubmed-38441782013-12-08 Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients Kawamoto, Ryuichi Katoh, Tateaki Kusunoki, Tomo Ohtsuka, Nobuyuki ISRN Endocrinol Clinical Study Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on the presence of CVD. We cross-sectionally assessed the ability of carotid IMT to identify CVD corresponding to treatment that was examined by receiver-operating characteristic (ROC) curve analyses. Among the 271 diabetic patients, 199 non-CVD and 72 CVD patients were examined. Multiple linear regression analysis using the presence of CVD as an objective variable showed that carotid IMT (β = 0.259, P < 0.001) as well as other confounding factors was a significant independent contributing factor. The ROC curve analysis showed that the best marker of CVD was carotid IMT, with an area under the ROC curve of 0.718 (95% confidence interval (CI), 0.650–0.785). The greatest sensitivity and specificity were obtained when the cut-off value of mean carotid IMT was set at 0.95 mm (sensitivity = 0.71, specificity = 0.60, and accuracy = 0.627). Our study suggests that carotid IMT may be useful for screening diabetic patients with CVD. Hindawi Publishing Corporation 2013-11-10 /pmc/articles/PMC3844178/ /pubmed/24319597 http://dx.doi.org/10.1155/2013/979481 Text en Copyright © 2013 Ryuichi Kawamoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kawamoto, Ryuichi
Katoh, Tateaki
Kusunoki, Tomo
Ohtsuka, Nobuyuki
Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title_full Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title_fullStr Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title_full_unstemmed Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title_short Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
title_sort carotid atherosclerosis as a surrogate maker of cardiovascular disease in diabetic patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844178/
https://www.ncbi.nlm.nih.gov/pubmed/24319597
http://dx.doi.org/10.1155/2013/979481
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