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Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients
Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844178/ https://www.ncbi.nlm.nih.gov/pubmed/24319597 http://dx.doi.org/10.1155/2013/979481 |
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author | Kawamoto, Ryuichi Katoh, Tateaki Kusunoki, Tomo Ohtsuka, Nobuyuki |
author_facet | Kawamoto, Ryuichi Katoh, Tateaki Kusunoki, Tomo Ohtsuka, Nobuyuki |
author_sort | Kawamoto, Ryuichi |
collection | PubMed |
description | Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on the presence of CVD. We cross-sectionally assessed the ability of carotid IMT to identify CVD corresponding to treatment that was examined by receiver-operating characteristic (ROC) curve analyses. Among the 271 diabetic patients, 199 non-CVD and 72 CVD patients were examined. Multiple linear regression analysis using the presence of CVD as an objective variable showed that carotid IMT (β = 0.259, P < 0.001) as well as other confounding factors was a significant independent contributing factor. The ROC curve analysis showed that the best marker of CVD was carotid IMT, with an area under the ROC curve of 0.718 (95% confidence interval (CI), 0.650–0.785). The greatest sensitivity and specificity were obtained when the cut-off value of mean carotid IMT was set at 0.95 mm (sensitivity = 0.71, specificity = 0.60, and accuracy = 0.627). Our study suggests that carotid IMT may be useful for screening diabetic patients with CVD. |
format | Online Article Text |
id | pubmed-3844178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38441782013-12-08 Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients Kawamoto, Ryuichi Katoh, Tateaki Kusunoki, Tomo Ohtsuka, Nobuyuki ISRN Endocrinol Clinical Study Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on the presence of CVD. We cross-sectionally assessed the ability of carotid IMT to identify CVD corresponding to treatment that was examined by receiver-operating characteristic (ROC) curve analyses. Among the 271 diabetic patients, 199 non-CVD and 72 CVD patients were examined. Multiple linear regression analysis using the presence of CVD as an objective variable showed that carotid IMT (β = 0.259, P < 0.001) as well as other confounding factors was a significant independent contributing factor. The ROC curve analysis showed that the best marker of CVD was carotid IMT, with an area under the ROC curve of 0.718 (95% confidence interval (CI), 0.650–0.785). The greatest sensitivity and specificity were obtained when the cut-off value of mean carotid IMT was set at 0.95 mm (sensitivity = 0.71, specificity = 0.60, and accuracy = 0.627). Our study suggests that carotid IMT may be useful for screening diabetic patients with CVD. Hindawi Publishing Corporation 2013-11-10 /pmc/articles/PMC3844178/ /pubmed/24319597 http://dx.doi.org/10.1155/2013/979481 Text en Copyright © 2013 Ryuichi Kawamoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Kawamoto, Ryuichi Katoh, Tateaki Kusunoki, Tomo Ohtsuka, Nobuyuki Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title | Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title_full | Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title_fullStr | Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title_full_unstemmed | Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title_short | Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients |
title_sort | carotid atherosclerosis as a surrogate maker of cardiovascular disease in diabetic patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844178/ https://www.ncbi.nlm.nih.gov/pubmed/24319597 http://dx.doi.org/10.1155/2013/979481 |
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