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Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury

Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cell...

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Detalles Bibliográficos
Autores principales: Chen, Shan, Meng, Xian-Fang, Zhang, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844218/
https://www.ncbi.nlm.nih.gov/pubmed/24319690
http://dx.doi.org/10.1155/2013/839761
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author Chen, Shan
Meng, Xian-Fang
Zhang, Chun
author_facet Chen, Shan
Meng, Xian-Fang
Zhang, Chun
author_sort Chen, Shan
collection PubMed
description Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury.
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spelling pubmed-38442182013-12-08 Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury Chen, Shan Meng, Xian-Fang Zhang, Chun Biomed Res Int Review Article Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury. Hindawi Publishing Corporation 2013 2013-11-11 /pmc/articles/PMC3844218/ /pubmed/24319690 http://dx.doi.org/10.1155/2013/839761 Text en Copyright © 2013 Shan Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Shan
Meng, Xian-Fang
Zhang, Chun
Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title_full Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title_fullStr Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title_full_unstemmed Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title_short Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
title_sort role of nadph oxidase-mediated reactive oxygen species in podocyte injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844218/
https://www.ncbi.nlm.nih.gov/pubmed/24319690
http://dx.doi.org/10.1155/2013/839761
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