Cargando…
Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cell...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844218/ https://www.ncbi.nlm.nih.gov/pubmed/24319690 http://dx.doi.org/10.1155/2013/839761 |
_version_ | 1782293137806327808 |
---|---|
author | Chen, Shan Meng, Xian-Fang Zhang, Chun |
author_facet | Chen, Shan Meng, Xian-Fang Zhang, Chun |
author_sort | Chen, Shan |
collection | PubMed |
description | Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury. |
format | Online Article Text |
id | pubmed-3844218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38442182013-12-08 Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury Chen, Shan Meng, Xian-Fang Zhang, Chun Biomed Res Int Review Article Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury. Hindawi Publishing Corporation 2013 2013-11-11 /pmc/articles/PMC3844218/ /pubmed/24319690 http://dx.doi.org/10.1155/2013/839761 Text en Copyright © 2013 Shan Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Shan Meng, Xian-Fang Zhang, Chun Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title | Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title_full | Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title_fullStr | Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title_full_unstemmed | Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title_short | Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury |
title_sort | role of nadph oxidase-mediated reactive oxygen species in podocyte injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844218/ https://www.ncbi.nlm.nih.gov/pubmed/24319690 http://dx.doi.org/10.1155/2013/839761 |
work_keys_str_mv | AT chenshan roleofnadphoxidasemediatedreactiveoxygenspeciesinpodocyteinjury AT mengxianfang roleofnadphoxidasemediatedreactiveoxygenspeciesinpodocyteinjury AT zhangchun roleofnadphoxidasemediatedreactiveoxygenspeciesinpodocyteinjury |