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Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity

The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learn...

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Detalles Bibliográficos
Autores principales: Cheron, Guy, Dan, Bernard, Márquez-Ruiz, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844268/
https://www.ncbi.nlm.nih.gov/pubmed/24319600
http://dx.doi.org/10.1155/2013/853654
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author Cheron, Guy
Dan, Bernard
Márquez-Ruiz, Javier
author_facet Cheron, Guy
Dan, Bernard
Márquez-Ruiz, Javier
author_sort Cheron, Guy
collection PubMed
description The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the Purkinje cells specifically controlled by the climbing fiber represents a major element within the feed-forward and feedback loops of the cerebellar cortex. Reciprocally connected with the basal ganglia and multimodal cerebral domains, this cerebellar network may realize fundamental functions in a wide range of behaviors. This review will outline the current understanding of three main experimental paradigms largely used for revealing cerebellar functions in behavioral learning: (1) the vestibuloocular reflex and smooth pursuit control, (2) the eyeblink conditioning, and (3) the sensory envelope plasticity. For each of these experimental conditions, we have critically revisited the chain of causalities linking together neural circuits, neural signals, and plasticity mechanisms, giving preference to behaving or alert animal physiology. Namely, recent experimental approaches mixing neural units and local field potentials recordings have demonstrated a spike timing dependent plasticity by which the cerebellum remains at a strategic crossroad for deciphering fundamental and translational mechanisms from cellular to network levels.
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spelling pubmed-38442682013-12-08 Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity Cheron, Guy Dan, Bernard Márquez-Ruiz, Javier Neural Plast Review Article The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the Purkinje cells specifically controlled by the climbing fiber represents a major element within the feed-forward and feedback loops of the cerebellar cortex. Reciprocally connected with the basal ganglia and multimodal cerebral domains, this cerebellar network may realize fundamental functions in a wide range of behaviors. This review will outline the current understanding of three main experimental paradigms largely used for revealing cerebellar functions in behavioral learning: (1) the vestibuloocular reflex and smooth pursuit control, (2) the eyeblink conditioning, and (3) the sensory envelope plasticity. For each of these experimental conditions, we have critically revisited the chain of causalities linking together neural circuits, neural signals, and plasticity mechanisms, giving preference to behaving or alert animal physiology. Namely, recent experimental approaches mixing neural units and local field potentials recordings have demonstrated a spike timing dependent plasticity by which the cerebellum remains at a strategic crossroad for deciphering fundamental and translational mechanisms from cellular to network levels. Hindawi Publishing Corporation 2013 2013-11-11 /pmc/articles/PMC3844268/ /pubmed/24319600 http://dx.doi.org/10.1155/2013/853654 Text en Copyright © 2013 Guy Cheron et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cheron, Guy
Dan, Bernard
Márquez-Ruiz, Javier
Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title_full Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title_fullStr Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title_full_unstemmed Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title_short Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
title_sort translational approach to behavioral learning: lessons from cerebellar plasticity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844268/
https://www.ncbi.nlm.nih.gov/pubmed/24319600
http://dx.doi.org/10.1155/2013/853654
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