Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study

Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope a...

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Autores principales: Nakazawa, Mitsuru, Suzuki, Yukihiko, Ito, Tadashi, Metoki, Tomomi, Kudo, Takashi, Ohguro, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844269/
https://www.ncbi.nlm.nih.gov/pubmed/24319686
http://dx.doi.org/10.1155/2013/585729
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author Nakazawa, Mitsuru
Suzuki, Yukihiko
Ito, Tadashi
Metoki, Tomomi
Kudo, Takashi
Ohguro, Hiroshi
author_facet Nakazawa, Mitsuru
Suzuki, Yukihiko
Ito, Tadashi
Metoki, Tomomi
Kudo, Takashi
Ohguro, Hiroshi
author_sort Nakazawa, Mitsuru
collection PubMed
description Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). Results. The mean MD slopes were −0.55/−0.39 (right/left eyes, n = 19) dB/year in the treated group and −1.37/−1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. Conclusion. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.
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spelling pubmed-38442692013-12-08 Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study Nakazawa, Mitsuru Suzuki, Yukihiko Ito, Tadashi Metoki, Tomomi Kudo, Takashi Ohguro, Hiroshi Biomed Res Int Clinical Study Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). Results. The mean MD slopes were −0.55/−0.39 (right/left eyes, n = 19) dB/year in the treated group and −1.37/−1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. Conclusion. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP. Hindawi Publishing Corporation 2013 2013-11-12 /pmc/articles/PMC3844269/ /pubmed/24319686 http://dx.doi.org/10.1155/2013/585729 Text en Copyright © 2013 Mitsuru Nakazawa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Nakazawa, Mitsuru
Suzuki, Yukihiko
Ito, Tadashi
Metoki, Tomomi
Kudo, Takashi
Ohguro, Hiroshi
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title_full Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title_fullStr Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title_full_unstemmed Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title_short Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
title_sort long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844269/
https://www.ncbi.nlm.nih.gov/pubmed/24319686
http://dx.doi.org/10.1155/2013/585729
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