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Simultaneous identification of 36 mutations in KRAS codons 61and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit

BACKGROUND: Retrospective analyses in the West suggest that mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA are negative predictive factors for cetuximab treatment in colorectal cancer patients. We developed a novel multiplex kit detecting 36 mutations in KRAS codons 61 and 146, BRAF, NR...

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Detalles Bibliográficos
Autores principales:	Bando, Hideaki, Yoshino, Takayuki, Shinozaki, Eiji, Nishina, Tomohiro, Yamazaki, Kentaro, Yamaguchi, Kensei, Yuki, Satoshi, Kajiura, Shinya, Fujii, Satoshi, Yamanaka, Takeharu, Tsuchihara, Katsuya, Ohtsu, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Technical Advance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844320/ https://www.ncbi.nlm.nih.gov/pubmed/24006859 http://dx.doi.org/10.1186/1471-2407-13-405

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