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Transcriptional downregulation of S1pr1 is required for establishment of resident memory CD8(+) T cells
Cell-mediated immunity critically depends on lymphocyte localization at sites of infection. While some memory T cells recirculate, a distinct lineage (resident memory T cells; T(RM)) are embedded in non-lymphoid tissues (NLTs) and mediate potent protective immunity. However, the defining transcripti...
Autores principales: | Skon, Cara N., Lee, June-Yong, Anderson, Kristin G., Masopust, David, Hogquist, Kristin A., Jameson, Stephen C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844557/ https://www.ncbi.nlm.nih.gov/pubmed/24162775 http://dx.doi.org/10.1038/ni.2745 |
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