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Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands

BACKGROUND: To date, only a few risk factors for pancreatic cancer have been established. We examined prospectively relations between several medical conditions and pancreatic cancer incidence. METHODS: In 1986, 120 852 participants completed a baseline questionnaire on cancer risk factors, includin...

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Autores principales: Eijgenraam, P, Heinen, M M, Verhage, B A J, Keulemans, Y C, Schouten, L J, van den Brandt, P A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844907/
https://www.ncbi.nlm.nih.gov/pubmed/24149173
http://dx.doi.org/10.1038/bjc.2013.629
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author Eijgenraam, P
Heinen, M M
Verhage, B A J
Keulemans, Y C
Schouten, L J
van den Brandt, P A
author_facet Eijgenraam, P
Heinen, M M
Verhage, B A J
Keulemans, Y C
Schouten, L J
van den Brandt, P A
author_sort Eijgenraam, P
collection PubMed
description BACKGROUND: To date, only a few risk factors for pancreatic cancer have been established. We examined prospectively relations between several medical conditions and pancreatic cancer incidence. METHODS: In 1986, 120 852 participants completed a baseline questionnaire on cancer risk factors, including several self-reported physician diagnosed medical conditions. At baseline, a random subcohort of 5000 participants was selected using a case-cohort approach for analysis. After 16.3 years of follow-up, 448 pancreatic cancer cases (63% microscopically confirmed) were available for analysis. RESULTS: Diabetes mellitus type II and hepatitis were positively associated with pancreatic cancer risk (multivariable-adjusted hazard ratio: 1.79; 95% confidence interval: 1.12–2.87 and hazard ratio: 1.37; 95% confidence interval: 1.04–1.81, respectively). Furthermore, a positive trend in risk with increasing years of diagnosis of diabetes (P=0.004) and of hepatitis (P=0.02) was observed. However, an inverse association was observed between hypertension and pancreatic cancer risk, this was found among microscopically confirmed cases only (hazard ratio: 0.66; 95% confidence interval: 0.49–0.90), while years since diagnosis of hypertension significantly decreased cancer risk (P for trend=0.02). CONCLUSION: In this prospective study, a positive association was observed between self-reported physician diagnosed diabetes mellitus type II and hepatitis and pancreatic cancer risk, whereas an inverse association was observed with hypertension.
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spelling pubmed-38449072014-11-26 Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands Eijgenraam, P Heinen, M M Verhage, B A J Keulemans, Y C Schouten, L J van den Brandt, P A Br J Cancer Epidemiology BACKGROUND: To date, only a few risk factors for pancreatic cancer have been established. We examined prospectively relations between several medical conditions and pancreatic cancer incidence. METHODS: In 1986, 120 852 participants completed a baseline questionnaire on cancer risk factors, including several self-reported physician diagnosed medical conditions. At baseline, a random subcohort of 5000 participants was selected using a case-cohort approach for analysis. After 16.3 years of follow-up, 448 pancreatic cancer cases (63% microscopically confirmed) were available for analysis. RESULTS: Diabetes mellitus type II and hepatitis were positively associated with pancreatic cancer risk (multivariable-adjusted hazard ratio: 1.79; 95% confidence interval: 1.12–2.87 and hazard ratio: 1.37; 95% confidence interval: 1.04–1.81, respectively). Furthermore, a positive trend in risk with increasing years of diagnosis of diabetes (P=0.004) and of hepatitis (P=0.02) was observed. However, an inverse association was observed between hypertension and pancreatic cancer risk, this was found among microscopically confirmed cases only (hazard ratio: 0.66; 95% confidence interval: 0.49–0.90), while years since diagnosis of hypertension significantly decreased cancer risk (P for trend=0.02). CONCLUSION: In this prospective study, a positive association was observed between self-reported physician diagnosed diabetes mellitus type II and hepatitis and pancreatic cancer risk, whereas an inverse association was observed with hypertension. Nature Publishing Group 2013-11-26 2013-10-22 /pmc/articles/PMC3844907/ /pubmed/24149173 http://dx.doi.org/10.1038/bjc.2013.629 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Eijgenraam, P
Heinen, M M
Verhage, B A J
Keulemans, Y C
Schouten, L J
van den Brandt, P A
Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title_full Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title_fullStr Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title_full_unstemmed Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title_short Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands
title_sort diabetes type ii, other medical conditions and pancreatic cancer risk: a prospective study in the netherlands
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844907/
https://www.ncbi.nlm.nih.gov/pubmed/24149173
http://dx.doi.org/10.1038/bjc.2013.629
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